Effect of hydroxypropyl-β-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis

The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl β-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1993-09, Vol.32 (3), p.459-463
Hauptverfasser:	Hostetler, John S., Hanson, Linda H., Stevens, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents beta-Cyclodextrins Biological and medical sciences Cryptococcosis - drug therapy Cryptococcosis - microbiology Cyclodextrins - pharmacology Excipients Female Itraconazole - administration & dosage Itraconazole - pharmacology Medical sciences Mice Pharmacology. Drug treatments Polyethylene Glycols Solutions
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Zusammenfassung:	The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl β-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses ≥ 30 mg/kg/day solubilized in hydroxypropyl-β-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/32.3.459