Electrophoretic analysis of myosin heavy chain isoform patterns in extraocular muscles of the rat

Six oculorotatory muscles and the levator palpebrae muscle of the rat were analysed by SDS-PAGE for their myosin heavy chain (MHC) isoform patterns. Oculorotatory muscles display a marked predominance of fast MHC isoforms. They contain, in addition to the slow (MHCI) and fast (MHCIIb, MHCIId, MHCIIa...

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Veröffentlicht in:	FEBS letters 1993-12, Vol.335 (2), p.243-245
Hauptverfasser:	Asmussen, Gerhard, Traub, Irmtrud, Pette, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Contractile proteins Electrophoresis Electrophoresis, Polyacrylamide Gel Extraocular muscle Fundamental and applied biological sciences. Psychology Holoproteins Myosin heavy chain isoform Myosins - analysis Oculomotor Muscles - chemistry Oculomotor Muscles - innervation Proteins Rat Rats Rats, Wistar
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Zusammenfassung:	Six oculorotatory muscles and the levator palpebrae muscle of the rat were analysed by SDS-PAGE for their myosin heavy chain (MHC) isoform patterns. Oculorotatory muscles display a marked predominance of fast MHC isoforms. They contain, in addition to the slow (MHCI) and fast (MHCIIb, MHCIId, MHCIIa) skeletal MHCs, the neonatal MHC neo and the extraocular MHC eom. The levator palpebrae, generally assumed to be a member of the extraocular muscle group because of its innervation by the ocolumotor nerve, does not contain MHC neo and MHC eom. It resembles a fast-twitch skeletal muscle with a predominance of MHCIId.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(93)80738-G