Vasoactive intestinal peptide: a growth promoter in neuroblastoma cells

Vasoactive intestinal peptide: a growth promoter in neuroblastoma cells

Vasoactive intestinal peptide (VIP) is a neuromodulator, growth regulator and secretagogue for neuronal survival factors. Moreover, VIP has been suggested to be a mitogenic factor for embryonic neurons in the sympathetic nervous system. We now show that VIP had mitogenic activity in a human neurobla...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Brain research 1993-10, Vol.624 (1-2), p.339-341
Hauptverfasser: Wollman, Y, Lilling, G, Goldstein, M N, Fridkin, M, Gozes, I
Format: Artikel
Sprache:eng
Schlagworte:
Blotting, Northern
Cell Division - drug effects
Dose-Response Relationship, Drug
Growth Substances - pharmacology
Humans
Neuroblastoma - metabolism
Neuroblastoma - pathology
RNA, Messenger - metabolism
Tumor Cells, Cultured
Vasoactive Intestinal Peptide - genetics
Vasoactive Intestinal Peptide - pharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Vasoactive intestinal peptide (VIP) is a neuromodulator, growth regulator and secretagogue for neuronal survival factors. Moreover, VIP has been suggested to be a mitogenic factor for embryonic neurons in the sympathetic nervous system. We now show that VIP had mitogenic activity in a human neuroblastoma cell line (NMB), as measured by cell number and thymidine incorporation. This mitogenic activity was dose dependent and was decreased with culture maturation. Northern blot analysis revealed VIP mRNA transcripts in this cell line suggesting an autocrine role for VIP in neurogenesis.
ISSN:0006-8993