Ancylostoma caninum: Glutathione Stimulates Feeding in Third-Stage Larvae by a Sulfhydryl-Independent Mechanism

The reduced form of the tripeptide glutathione has been reported to reinitiate feeding by third-stage larvae of the hookworm Ancylostoma caninum. Investigations were conducted with the GSH analogue ophthalmic acid to determine the mechanism by which GSH stimulates feeding. Ophthalmic acid stimulated...

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Veröffentlicht in:	Experimental parasitology 1993-12, Vol.77 (4), p.489-491
Hauptverfasser:	Hawdon, J.M., Schad, G.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ALIMENTACION DE LOS ANIMALES ALIMENTATION DES ANIMAUX Ancylostoma - drug effects Ancylostoma - physiology ANCYLOSTOMA CANINUM Ancylostomiasis - parasitology ANIMAL FEEDING Animals Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Dogs ESTIMULO Feeding Behavior - drug effects Fundamental and applied biological sciences. Psychology Glutathione - pharmacology HOST PARASITE RELATIONS Invertebrates Larva - drug effects Larva - physiology LARVAE LARVAS LARVE MODE OF ACTION Nemathelminthia. Plathelmintha PEPTIDE PEPTIDES PEPTIDOS Physiology. Development RELACIONES HUESPED PARASITO RELATION HOTE PARASITE STIMULATION STIMULI STIMULUS Sulfhydryl Compounds - pharmacology
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Zusammenfassung:	The reduced form of the tripeptide glutathione has been reported to reinitiate feeding by third-stage larvae of the hookworm Ancylostoma caninum. Investigations were conducted with the GSH analogue ophthalmic acid to determine the mechanism by which GSH stimulates feeding. Ophthalmic acid stimulated feeding, beginning at 1-2.5 mM and reaching a maximum by 10-15 mM, and also enhanced serum-stimulated feeding. The results indicate that GSH stimulates feeding by a specific, sulfhydryl-independent mechanism.
ISSN:	0014-4894 1090-2449
DOI:	10.1006/expr.1993.1110