Regulatory T Cells and T Helper Subsets in Breast‐fed Infants With Hematochezia Caused by Allergic Colitis

ABSTRACT The objective of our study was to investigate the prevalence of CD4+ T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence o...

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Veröffentlicht in:	Journal of pediatric gastroenterology and nutrition 2010-11, Vol.51 (5), p.675-677
Hauptverfasser:	Cseh, Áron, Molnár, Kriszta, Pintér, Petra, Szalay, Balazs, Szebeni, Beata, Treszl, Andras, Arató, Andras, Vásárhelyi, Barna, Veres, Gabor
Format:	Artikel
Sprache:	eng
Schlagworte:	allergic colitis Allergic diseases Amino Acids - pharmacology Amino Acids - therapeutic use Antigens - immunology Biological and medical sciences Breast Feeding Case-Control Studies CD4 Antigens Colitis - immunology Digestive allergic diseases Feeding. Feeding behavior Female food allergy Food Hypersensitivity - immunology Forkhead Transcription Factors - immunology Fundamental and applied biological sciences. Psychology Gastrointestinal Hemorrhage - immunology hematochezia Humans Immunopathology Infant Infant Formula infants Interleukin-2 Receptor alpha Subunit Lymphocyte Activation Male Medical sciences Milk, Human - immunology T-Lymphocytes, Regulatory - drug effects Th1-Th2 Balance Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	ABSTRACT The objective of our study was to investigate the prevalence of CD4+ T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence of activated CD4+CD25+ cells and FoxP3+ regulatory cells, and a shift to TH2 direction in balance compared with controls. These alterations are normalized upon cessation of AC symptoms on elemental L‐amino acid formula. These findings suggest the importance of antigen exposure in AC in infancy.
ISSN:	0277-2116 1536-4801
DOI:	10.1097/MPG.0b013e3181e85b22