Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients

Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in...

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Veröffentlicht in:	Fertility and sterility 2010-11, Vol.94 (6), p.2486-2489.e2
Hauptverfasser:	Wang, Lei, Ph.D, Wang, Ying, M.M, Zhang, Xiaoping, M.B, Shi, Juanzi, M.D, Wang, Min, M.B, Wei, Zhiyun, B.S, Zhao, Aman, B.S, Li, Baojie, Ph.D, Zhao, Xinzhi, Ph.D, Xing, Qinghe, Ph.D, He, Lin, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Case-Control Studies Female Female genital diseases Gene Frequency Genetic Predisposition to Disease Genetic Variation Glucose - metabolism Glucose Intolerance - complications Glucose Intolerance - genetics Glucose Tolerance Test Gynecology. Andrology. Obstetrics Humans Insulin - metabolism Insulin Secretion Internal Medicine Medical sciences Non tumoral diseases Obstetrics and Gynecology Phenotype Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Polymorphism, Single Nucleotide Receptor, Melatonin, MT2 - genetics Testosterone - blood
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Zusammenfassung:	Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in the pathophysiology of the disease.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2010.01.059