Absorption of pentacaine from ulcerous rat stomach

Pentacaine is a local anaesthetic which exhibited positive effects on healing of model ulcers in the rat stomach. The in situ disappearance of pentacaine from the ulcerous and intact rat stomach was studied. Gastric ulcers were produced by oral administration of phenylbutazone (200 mg . kg-1) 3.5 h...

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Veröffentlicht in:	Pharmazie 1985, Vol.40 (1), p.48-49
Hauptverfasser:	TOMCIKOVA, O, BABULOVA, A, DURISOVA, M, TRNOVEC, T, BENES, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Anesthetics, Local - metabolism Anesthetics. Neuromuscular blocking agents Animals Applied sciences Biological and medical sciences Carbamates - metabolism Exact sciences and technology Female Medical sciences Neuropharmacology Other techniques and industries Pharmacology. Drug treatments Rats Rats, Inbred Strains Stomach Ulcer - metabolism Time Factors
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Zusammenfassung:	Pentacaine is a local anaesthetic which exhibited positive effects on healing of model ulcers in the rat stomach. The in situ disappearance of pentacaine from the ulcerous and intact rat stomach was studied. Gastric ulcers were produced by oral administration of phenylbutazone (200 mg . kg-1) 3.5 h before absorption experiment. Pentacaine exhibited a biexponential decrease from the lumen of the stomach, the rate of which was essentially the same in both groups. The total amount of pentacaine absorbed was small because of extremely low absorption rate.
ISSN:	0031-7144