Interference with high performance liquid chromatographic chloramphenicol assay in a patient receiving dobutamine

We report potential interference by dobutamine with our high performance liquid chromatography (HPLC) procedure for assaying chloramphenicol succinate and chloramphenicol. Interference was discovered in a 1-year-old boy receiving chloramphenicol succinate and dobutamine. The identity of the interfer...

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Veröffentlicht in:	Therapeutic drug monitoring 1985-01, Vol.7 (1), p.121-122
Hauptverfasser:	POWEL, M. B, ROBINSON, C. A, FURNER, R. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Catecholamines - blood Chloramphenicol - analogs & derivatives Chloramphenicol - blood Chloramphenicol - therapeutic use Chromatography, Gas Chromatography, High Pressure Liquid Dobutamine - blood General pharmacology Humans Infant Male Medical sciences Monitoring, Physiologic Pharmacology. Drug treatments Postoperative Complications - drug therapy Staphylococcal Infections - drug therapy
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Beschreibung
Zusammenfassung:	We report potential interference by dobutamine with our high performance liquid chromatography (HPLC) procedure for assaying chloramphenicol succinate and chloramphenicol. Interference was discovered in a 1-year-old boy receiving chloramphenicol succinate and dobutamine. The identity of the interfering substance was confirmed by HPLC and gas chromatography.
ISSN:	0163-4356 1536-3694
DOI:	10.1097/00007691-198503000-00021