Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat
The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Pros...
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Veröffentlicht in: | Regulatory peptides 1985-03, Vol.10 (2), p.231-236 |
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creator | Mogard, M.H. Kauffman, G.L. Pehlevanian, M. Golanska, E. Elashoff, J.D. Walsh, J.H. |
description | The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Prostaglandin synthesis inhibition ( |
doi_str_mv | 10.1016/0167-0115(85)90017-5 |
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2-generation assay on gastric mucosal tissue. In both conscious and anesthetized rats somatostatin significantly inhibited the stimulated acid output in the control and indomethacin pretreated groups. The present findings do not support a role for prostaglandins in the inhibition of gastric acid secretion by somatostatin in the rat.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(85)90017-5</identifier><identifier>PMID: 2859639</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Anesthesia ; Animals ; Bethanechol Compounds - pharmacology ; Biological and medical sciences ; Dinoprostone ; Fundamental and applied biological sciences. Psychology ; Gastric Acid - metabolism ; gastric acid secretion ; Gastric Mucosa - metabolism ; indomethacin ; Indomethacin - pharmacology ; prostaglandins ; Prostaglandins - physiology ; Prostaglandins E - biosynthesis ; rat ; Rats ; somatostatin ; Somatostatin - physiology ; Stomach ; Vertebrates: digestive system</subject><ispartof>Regulatory peptides, 1985-03, Vol.10 (2), p.231-236</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-36726d9e7feae810d28f765149eaf4c574be6970346778551b9589b4b160fcc13</citedby><cites>FETCH-LOGICAL-c386t-36726d9e7feae810d28f765149eaf4c574be6970346778551b9589b4b160fcc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0167-0115(85)90017-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9212653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2859639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mogard, M.H.</creatorcontrib><creatorcontrib>Kauffman, G.L.</creatorcontrib><creatorcontrib>Pehlevanian, M.</creatorcontrib><creatorcontrib>Golanska, E.</creatorcontrib><creatorcontrib>Elashoff, J.D.</creatorcontrib><creatorcontrib>Walsh, J.H.</creatorcontrib><title>Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Prostaglandin synthesis inhibition (<90%) by indomethacin was verified with PGE
2-generation assay on gastric mucosal tissue. In both conscious and anesthetized rats somatostatin significantly inhibited the stimulated acid output in the control and indomethacin pretreated groups. The present findings do not support a role for prostaglandins in the inhibition of gastric acid secretion by somatostatin in the rat.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Bethanechol Compounds - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dinoprostone</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Acid - metabolism</subject><subject>gastric acid secretion</subject><subject>Gastric Mucosa - metabolism</subject><subject>indomethacin</subject><subject>Indomethacin - pharmacology</subject><subject>prostaglandins</subject><subject>Prostaglandins - physiology</subject><subject>Prostaglandins E - biosynthesis</subject><subject>rat</subject><subject>Rats</subject><subject>somatostatin</subject><subject>Somatostatin - physiology</subject><subject>Stomach</subject><subject>Vertebrates: digestive system</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQCELEV2MJjOT20aQ4g0KutCtIZM500Y6MzVJhb696YUuXYSzON__k_MhdE7JLSWU36UnMkIpu5bsRhFCRcYO0JBKUWSUS36IhnvkGJ2E8J0YJkQxQINcMsULNURf774P0UznpqtdF3BrVrjrI26hdiYCdt3MVS66vsN9g6cmRO8sNtbVOID1sNlUKxz61sR1U3RdCuE4A-xNPEVHjZkHONvNEfp8evwYv2STt-fX8cMks4XkMSu4yHmtQDRgQFJS57IRnNFSgWlKy0RZAVeCFCUXQjJGK8WkqsqKctJYS4sRutr2Lnz_s4QQdeuChXk6C_pl0IITJUqlElhuQZvuDh4avfCuNX6lKdFrrXrtTK-dacn0RqtmKXax619WSc0-tPOY9pe7vQnWzBtvOuvCHlM5zTkrEna_xSC5-HXgdbAOOptke7BR1737_x9_m96TpA</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>Mogard, M.H.</creator><creator>Kauffman, G.L.</creator><creator>Pehlevanian, M.</creator><creator>Golanska, E.</creator><creator>Elashoff, J.D.</creator><creator>Walsh, J.H.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat</title><author>Mogard, M.H. ; Kauffman, G.L. ; Pehlevanian, M. ; Golanska, E. ; Elashoff, J.D. ; Walsh, J.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-36726d9e7feae810d28f765149eaf4c574be6970346778551b9589b4b160fcc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Bethanechol Compounds - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dinoprostone</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Acid - metabolism</topic><topic>gastric acid secretion</topic><topic>Gastric Mucosa - metabolism</topic><topic>indomethacin</topic><topic>Indomethacin - pharmacology</topic><topic>prostaglandins</topic><topic>Prostaglandins - physiology</topic><topic>Prostaglandins E - biosynthesis</topic><topic>rat</topic><topic>Rats</topic><topic>somatostatin</topic><topic>Somatostatin - physiology</topic><topic>Stomach</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mogard, M.H.</creatorcontrib><creatorcontrib>Kauffman, G.L.</creatorcontrib><creatorcontrib>Pehlevanian, M.</creatorcontrib><creatorcontrib>Golanska, E.</creatorcontrib><creatorcontrib>Elashoff, J.D.</creatorcontrib><creatorcontrib>Walsh, J.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mogard, M.H.</au><au>Kauffman, G.L.</au><au>Pehlevanian, M.</au><au>Golanska, E.</au><au>Elashoff, J.D.</au><au>Walsh, J.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1985-03</date><risdate>1985</risdate><volume>10</volume><issue>2</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Prostaglandin synthesis inhibition (<90%) by indomethacin was verified with PGE
2-generation assay on gastric mucosal tissue. In both conscious and anesthetized rats somatostatin significantly inhibited the stimulated acid output in the control and indomethacin pretreated groups. The present findings do not support a role for prostaglandins in the inhibition of gastric acid secretion by somatostatin in the rat.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2859639</pmid><doi>10.1016/0167-0115(85)90017-5</doi><tpages>6</tpages></addata></record> |
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subjects | Anesthesia Animals Bethanechol Compounds - pharmacology Biological and medical sciences Dinoprostone Fundamental and applied biological sciences. Psychology Gastric Acid - metabolism gastric acid secretion Gastric Mucosa - metabolism indomethacin Indomethacin - pharmacology prostaglandins Prostaglandins - physiology Prostaglandins E - biosynthesis rat Rats somatostatin Somatostatin - physiology Stomach Vertebrates: digestive system |
title | Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat |
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