Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat

Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat

The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Pros...

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Veröffentlicht in:Regulatory peptides 1985-03, Vol.10 (2), p.231-236
Hauptverfasser: Mogard, M.H., Kauffman, G.L., Pehlevanian, M., Golanska, E., Elashoff, J.D., Walsh, J.H.
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Animals
Bethanechol Compounds - pharmacology
Biological and medical sciences
Dinoprostone
Fundamental and applied biological sciences. Psychology
Gastric Acid - metabolism
gastric acid secretion
Gastric Mucosa - metabolism
indomethacin
Indomethacin - pharmacology
prostaglandins
Prostaglandins - physiology
Prostaglandins E - biosynthesis
rat
Rats
somatostatin
Somatostatin - physiology
Stomach
Vertebrates: digestive system
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Zusammenfassung:The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Prostaglandin synthesis inhibition (
ISSN:0167-0115
1873-1686
DOI:10.1016/0167-0115(85)90017-5