Effect of Platelet-Associated Virus on Assays of HIV-1 in Plasma

High concentrations of RNA from human immunodeficiency virus-type 1 (HIV-1) in the plasma of 66 seropositive patients may be due, at least partially, to the use of a QC-PCR assay that did not account for contribution to viremia of HIV-1 associated with platelets.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-12, Vol.262 (5139), p.1585-1586
Hauptverfasser:	Lee, Tzong-Hae, Stromberg, Robert R., Henrard, Denis, Busch, Michael P., Piatak, Michael, Shaw, George M., Yang, Limei C., Kappes, John C., Saag, Michael S., Lifson, Jeffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS/HIV Blood Blood plasma Blood Platelets - microbiology Centrifugation Genetic aspects HIV HIV (Viruses) HIV 1 HIV positive HIV seropositivity HIV-1 - isolation & purification human immunodeficiency virus 1 Humans Plasma - microbiology Platelets Reverse transcriptase polymerase chain reaction RNA RNA, Viral - blood Technical Comments Viral RNA Viruses
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Beschreibung
Zusammenfassung:	High concentrations of RNA from human immunodeficiency virus-type 1 (HIV-1) in the plasma of 66 seropositive patients may be due, at least partially, to the use of a QC-PCR assay that did not account for contribution to viremia of HIV-1 associated with platelets.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.8248811