Fibroblast growth factor in the human placenta

Fibroblast growth factor in the human placenta

Fibroblast growth factor (FGF) has been purified 333,000-fold from human placenta by a combination of salt precipitation, cation-exchange chromatography, and Heparin-Sepharose affinity chromatography. Molecular weight (15–16 kDaltons), amino acid composition, bioactivity and immunological crossreact...

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Veröffentlicht in:Biochemical and biophysical research communications 1985-04, Vol.128 (2), p.554-562
Hauptverfasser: Gospodarowicz, D., Cheng, J., Lui, G.-M., Fujii, D.K., Baird, A., Böhlen, P.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - analysis
Animals
Applied sciences
Cattle
Chromatography, Affinity
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Cross Reactions
Exact sciences and technology
Female
fibroblast growth factor
Fibroblast Growth Factors - immunology
Fibroblast Growth Factors - isolation & purification
Humans
man
Molecular Weight
Other techniques and industries
Pituitary Gland - analysis
placenta
Placenta - analysis
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
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Zusammenfassung:Fibroblast growth factor (FGF) has been purified 333,000-fold from human placenta by a combination of salt precipitation, cation-exchange chromatography, and Heparin-Sepharose affinity chromatography. Molecular weight (15–16 kDaltons), amino acid composition, bioactivity and immunological crossreactivity with bovine pituitary FGF indicate that the mitogens from the two species are closely related molecules.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(85)90082-8