Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: Application to N, N-dimethylformamide
The metabolism of N, N-dimethylformamide in the Sprague—Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of N, N-dimethylformamide-d 7 (DMF-d 7) and 2H-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manne...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1993-08, Vol.11 (8), p.687-692 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 11 |
| creator | Farrant, R.Duncan Salman, Salman R. Lindon, John C. Cupid, Belinda C. Nicholson, Jeremy K. |
| description | The metabolism of
N,
N-dimethylformamide in the Sprague—Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of
N,
N-dimethylformamide-d
7 (DMF-d
7) and
2H-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional
2H
13C correlation with
13C decoupling aided metabolite identification through the provision of
13C chemical shifts. |
| doi_str_mv | 10.1016/0731-7085(93)80175-Z |
| format | Article |
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N,
N-dimethylformamide in the Sprague—Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of
N,
N-dimethylformamide-d
7 (DMF-d
7) and
2H-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional
2H
13C correlation with
13C decoupling aided metabolite identification through the provision of
13C chemical shifts.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/0731-7085(93)80175-Z</identifier><identifier>PMID: 8257732</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>2H-NMR ; 2H 13C correlation ; Analysis ; Animals ; Biological and medical sciences ; Deuterium ; Dimethylformamide - metabolism ; DMF ; General pharmacology ; Injections, Intraperitoneal ; Magnetic Resonance Spectroscopy ; Medical sciences ; metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; urine ; Urine - chemistry</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 1993-08, Vol.11 (8), p.687-692</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-b9d7e8808999323257940bc5e25e9e1fd735f19c12ecd5487f5de75ed54c6ed43</citedby><cites>FETCH-LOGICAL-c386t-b9d7e8808999323257940bc5e25e9e1fd735f19c12ecd5487f5de75ed54c6ed43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0731-7085(93)80175-Z$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4878601$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8257732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farrant, R.Duncan</creatorcontrib><creatorcontrib>Salman, Salman R.</creatorcontrib><creatorcontrib>Lindon, John C.</creatorcontrib><creatorcontrib>Cupid, Belinda C.</creatorcontrib><creatorcontrib>Nicholson, Jeremy K.</creatorcontrib><title>Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: Application to N, N-dimethylformamide</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>The metabolism of
N,
N-dimethylformamide in the Sprague—Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of
N,
N-dimethylformamide-d
7 (DMF-d
7) and
2H-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional
2H
13C correlation with
13C decoupling aided metabolite identification through the provision of
13C chemical shifts.</description><subject>2H-NMR</subject><subject>2H 13C correlation</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Deuterium</subject><subject>Dimethylformamide - metabolism</subject><subject>DMF</subject><subject>General pharmacology</subject><subject>Injections, Intraperitoneal</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>urine</subject><subject>Urine - chemistry</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo67j6DxRyIaJgNWmaJvFCWNZPWEcQBdmbkCYnbqRtapIK8-_NOONcepXAec7Ly3MQekjJC0po_5IIRhtBJH-q2DNJqODN9S20oVKwpu2777fR5oTcRfdy_kkI4VR1Z-hMtlwI1m7Q7g2sBVJYJ7z99AXnBWxJMdu47HD0eAjRj2twGfuYcLkBHBzMJfhgTQlx3jMurT_wBMUMcQwF8it8sSzjP6BEvH2Ot40LFbnZjTVnMlNNuY_ueDNmeHB8z9G3d2-_Xn5orj6__3h5cdVYJvvSDMoJkJJIpRRrWe2tOjJYDi0HBdQ7wbinytIWrOOdFJ47EBzq3_bgOnaOnhxylxR_rZCLnkK2MI5mhrhmLXqiWtL3FewOoK0CcgKvlxQmk3aaEr03rvc69V6nVkz_Na6v69qjY_46TOBOS0fFdf74ODfZmtEnM9uQT1htLHtCK_b6gEF18TtA0tkGmC24kOpNtIvh_z3-AE_vnqg</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>Farrant, R.Duncan</creator><creator>Salman, Salman R.</creator><creator>Lindon, John C.</creator><creator>Cupid, Belinda C.</creator><creator>Nicholson, Jeremy K.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930801</creationdate><title>Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: Application to N, N-dimethylformamide</title><author>Farrant, R.Duncan ; Salman, Salman R. ; Lindon, John C. ; Cupid, Belinda C. ; Nicholson, Jeremy K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b9d7e8808999323257940bc5e25e9e1fd735f19c12ecd5487f5de75ed54c6ed43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>2H-NMR</topic><topic>2H 13C correlation</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Deuterium</topic><topic>Dimethylformamide - metabolism</topic><topic>DMF</topic><topic>General pharmacology</topic><topic>Injections, Intraperitoneal</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>urine</topic><topic>Urine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrant, R.Duncan</creatorcontrib><creatorcontrib>Salman, Salman R.</creatorcontrib><creatorcontrib>Lindon, John C.</creatorcontrib><creatorcontrib>Cupid, Belinda C.</creatorcontrib><creatorcontrib>Nicholson, Jeremy K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrant, R.Duncan</au><au>Salman, Salman R.</au><au>Lindon, John C.</au><au>Cupid, Belinda C.</au><au>Nicholson, Jeremy K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: Application to N, N-dimethylformamide</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>11</volume><issue>8</issue><spage>687</spage><epage>692</epage><pages>687-692</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The metabolism of
N,
N-dimethylformamide in the Sprague—Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of
N,
N-dimethylformamide-d
7 (DMF-d
7) and
2H-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional
2H
13C correlation with
13C decoupling aided metabolite identification through the provision of
13C chemical shifts.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8257732</pmid><doi>10.1016/0731-7085(93)80175-Z</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1993-08, Vol.11 (8), p.687-692 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76092066 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 2H-NMR 2H 13C correlation Analysis Animals Biological and medical sciences Deuterium Dimethylformamide - metabolism DMF General pharmacology Injections, Intraperitoneal Magnetic Resonance Spectroscopy Medical sciences metabolism Pharmacology. Drug treatments Rats Rats, Sprague-Dawley urine Urine - chemistry |
| title | Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: Application to N, N-dimethylformamide |
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