The effects of gastric inhibitory polypeptide (GIP) on the release of anterior pituitary hormones
Several members of the secretin family of hormones have been demonstrated to alter anterior pituitary hormone secretion. Here we report the action of gastric inhibitory polypeptide (GIP) on gonadotropin and somatotropin release. Intraventricular injection of 1 μg (0.2 nmole) GIP (2.5 μl) produced a...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1985-01, Vol.6 (1), p.115-119 |
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| creator | Ottlecz, Anna Samson, Willis K. McCann, Samuel M. |
| description | Several members of the secretin family of hormones have been demonstrated to alter anterior pituitary hormone secretion. Here we report the action of gastric inhibitory polypeptide (GIP) on gonadotropin and somatotropin release. Intraventricular injection of 1 μg (0.2 nmole) GIP (2.5 μl) produced a significant decrease in plasma FSH at 30 (
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| doi_str_mv | 10.1016/0196-9781(85)90086-5 |
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p<0.02) and 60 min after its injection (
p<0.01). The FSH-lowering effect of a higher dose of 5 μg (1 nmole) of GIP was already developed at 15 min (
p<0.01) and was prolonged until the end of the experiment (60 min,
p<0.05). No change in plasma LH was detected at any time during the experimental period. If 5 μg of estradiol-benzoate were given SC 48 hr prior to experiment, the initial values of FSH and LH were markedly decreased. In these animals GIP failed to influence plasma FSH and LH. When dispersed anterior pituitary cells from OVX rats were cultured overnight and incubated
in vitro with GIP, the peptide was found to induce both FSH and LH release. Highly significant release occurred with the lowest dose tested of 10
−7 M and there was a dose-response effect for both hormones. The slope of the dose-response curve was similar for both FSH and LH release. GIP was less potent than LHRH which produced a greater stimulation of both FSH and LH release at a dose of 10
−9 M than did 10
−7 M GIP. The two peptides had an additive effect on the release of both FSH and LH. Intraventricular injection of 1 μg of GIP resulted in significantly elevated GH levels at 60 min and the higher dose of 5 μg gave a more pronounced increase which was significant 30 and 60 min after injection. Plasma levels of Prl and TSH were unaltered by intraventricular GIP. There was no effect of the peptide on the
in vitro release of GH, prolactin or TSH. Consequently, we conclude that GIP can act at relatively high doses and fairly slowly to stimulate GH release via hypothalamic action.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(85)90086-5</identifier><identifier>PMID: 3991358</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Castration ; Estradiol - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Gastric inhibitory polypeptide ; Gastric Inhibitory Polypeptide - administration & dosage ; Gastric Inhibitory Polypeptide - pharmacology ; Gastrointestinal Hormones - pharmacology ; GIP and pituitary hormone release ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Injections, Intraventricular ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - metabolism ; Pituitary Hormones, Anterior - metabolism ; Rats ; Rats, Inbred Strains ; Secretory Rate - drug effects ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 1985-01, Vol.6 (1), p.115-119</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-ef8d920f79a0b777cf5cb98f628919cf37352ea165bef3313b3b2d4353c4c59c3</citedby><cites>FETCH-LOGICAL-c483t-ef8d920f79a0b777cf5cb98f628919cf37352ea165bef3313b3b2d4353c4c59c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(85)90086-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8458429$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3991358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ottlecz, Anna</creatorcontrib><creatorcontrib>Samson, Willis K.</creatorcontrib><creatorcontrib>McCann, Samuel M.</creatorcontrib><title>The effects of gastric inhibitory polypeptide (GIP) on the release of anterior pituitary hormones</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Several members of the secretin family of hormones have been demonstrated to alter anterior pituitary hormone secretion. Here we report the action of gastric inhibitory polypeptide (GIP) on gonadotropin and somatotropin release. Intraventricular injection of 1 μg (0.2 nmole) GIP (2.5 μl) produced a significant decrease in plasma FSH at 30 (
p<0.02) and 60 min after its injection (
p<0.01). The FSH-lowering effect of a higher dose of 5 μg (1 nmole) of GIP was already developed at 15 min (
p<0.01) and was prolonged until the end of the experiment (60 min,
p<0.05). No change in plasma LH was detected at any time during the experimental period. If 5 μg of estradiol-benzoate were given SC 48 hr prior to experiment, the initial values of FSH and LH were markedly decreased. In these animals GIP failed to influence plasma FSH and LH. When dispersed anterior pituitary cells from OVX rats were cultured overnight and incubated
in vitro with GIP, the peptide was found to induce both FSH and LH release. Highly significant release occurred with the lowest dose tested of 10
−7 M and there was a dose-response effect for both hormones. The slope of the dose-response curve was similar for both FSH and LH release. GIP was less potent than LHRH which produced a greater stimulation of both FSH and LH release at a dose of 10
−9 M than did 10
−7 M GIP. The two peptides had an additive effect on the release of both FSH and LH. Intraventricular injection of 1 μg of GIP resulted in significantly elevated GH levels at 60 min and the higher dose of 5 μg gave a more pronounced increase which was significant 30 and 60 min after injection. Plasma levels of Prl and TSH were unaltered by intraventricular GIP. There was no effect of the peptide on the
in vitro release of GH, prolactin or TSH. Consequently, we conclude that GIP can act at relatively high doses and fairly slowly to stimulate GH release via hypothalamic action.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Castration</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric inhibitory polypeptide</subject><subject>Gastric Inhibitory Polypeptide - administration & dosage</subject><subject>Gastric Inhibitory Polypeptide - pharmacology</subject><subject>Gastrointestinal Hormones - pharmacology</subject><subject>GIP and pituitary hormone release</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Injections, Intraventricular</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Pituitary Hormones, Anterior - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Secretory Rate - drug effects</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1OJCEUhYlxou3PGzgJCzPRRY1QQAEbk4lRx8RkXOiaUNTFZlJdlECb-PZTNd3ppa5Y3O-cyz0HoTNKflJCmytCdVNpqeiFEpeaENVUYg8tqJKsErTR-2ixQw7RUc5_CSGca3WADpjWlAm1QPZ5CRi8B1cyjh6_2lxScDgMy9CGEtMHHmP_McJYQgf44v7h6RLHAZdJlqAHm2GW2aFACjHhMZR1KHaSLWNaxQHyCfrmbZ_hdPseo5e72-eb39Xjn_uHm1-PleOKlQq86nRNvNSWtFJK54VrtfJNrTTVzjPJRA2WNqIFzxhlLWvrjjPBHHdCO3aMfmx8xxTf1pCLWYXsoO_tAHGdjWyI0oSKL0HKGada6gnkG9ClmHMCb8YUVtNthhIzV2DmfM2cr1HC_K_AzP7ft_7rdgXdTrTNfJqfb-c2O9v7ZAcX8g5TXChez9uvNxhMob0HSCa7AIODLqSpLdPF8Pk__gFodKKQ</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Ottlecz, Anna</creator><creator>Samson, Willis K.</creator><creator>McCann, Samuel M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SQ</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>The effects of gastric inhibitory polypeptide (GIP) on the release of anterior pituitary hormones</title><author>Ottlecz, Anna ; Samson, Willis K. ; McCann, Samuel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ef8d920f79a0b777cf5cb98f628919cf37352ea165bef3313b3b2d4353c4c59c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Castration</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric inhibitory polypeptide</topic><topic>Gastric Inhibitory Polypeptide - administration & dosage</topic><topic>Gastric Inhibitory Polypeptide - pharmacology</topic><topic>Gastrointestinal Hormones - pharmacology</topic><topic>GIP and pituitary hormone release</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Injections, Intraventricular</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Pituitary Hormones, Anterior - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Secretory Rate - drug effects</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ottlecz, Anna</creatorcontrib><creatorcontrib>Samson, Willis K.</creatorcontrib><creatorcontrib>McCann, Samuel M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Endocrinology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ottlecz, Anna</au><au>Samson, Willis K.</au><au>McCann, Samuel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of gastric inhibitory polypeptide (GIP) on the release of anterior pituitary hormones</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>6</volume><issue>1</issue><spage>115</spage><epage>119</epage><pages>115-119</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Several members of the secretin family of hormones have been demonstrated to alter anterior pituitary hormone secretion. Here we report the action of gastric inhibitory polypeptide (GIP) on gonadotropin and somatotropin release. Intraventricular injection of 1 μg (0.2 nmole) GIP (2.5 μl) produced a significant decrease in plasma FSH at 30 (
p<0.02) and 60 min after its injection (
p<0.01). The FSH-lowering effect of a higher dose of 5 μg (1 nmole) of GIP was already developed at 15 min (
p<0.01) and was prolonged until the end of the experiment (60 min,
p<0.05). No change in plasma LH was detected at any time during the experimental period. If 5 μg of estradiol-benzoate were given SC 48 hr prior to experiment, the initial values of FSH and LH were markedly decreased. In these animals GIP failed to influence plasma FSH and LH. When dispersed anterior pituitary cells from OVX rats were cultured overnight and incubated
in vitro with GIP, the peptide was found to induce both FSH and LH release. Highly significant release occurred with the lowest dose tested of 10
−7 M and there was a dose-response effect for both hormones. The slope of the dose-response curve was similar for both FSH and LH release. GIP was less potent than LHRH which produced a greater stimulation of both FSH and LH release at a dose of 10
−9 M than did 10
−7 M GIP. The two peptides had an additive effect on the release of both FSH and LH. Intraventricular injection of 1 μg of GIP resulted in significantly elevated GH levels at 60 min and the higher dose of 5 μg gave a more pronounced increase which was significant 30 and 60 min after injection. Plasma levels of Prl and TSH were unaltered by intraventricular GIP. There was no effect of the peptide on the
in vitro release of GH, prolactin or TSH. Consequently, we conclude that GIP can act at relatively high doses and fairly slowly to stimulate GH release via hypothalamic action.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3991358</pmid><doi>10.1016/0196-9781(85)90086-5</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Castration Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Gastric inhibitory polypeptide Gastric Inhibitory Polypeptide - administration & dosage Gastric Inhibitory Polypeptide - pharmacology Gastrointestinal Hormones - pharmacology GIP and pituitary hormone release Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Pituitary Hormones, Anterior - metabolism Rats Rats, Inbred Strains Secretory Rate - drug effects Vertebrates: endocrinology |
| title | The effects of gastric inhibitory polypeptide (GIP) on the release of anterior pituitary hormones |
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