Preparation and Analysis of Deuterium-Labeled Aspirin: Application to Pharmacokinetic Studies

Preparation and Analysis of Deuterium-Labeled Aspirin: Application to Pharmacokinetic Studies

Inhibition of endogenous prostacyclin and thromboxane biosynthesis by aspirin is critically dose-dependent in humans. Gastrointestinal and hepatic hydrolysis may limit systemic availability of aspirin, especially in low doses, perhaps contributing to the biochemical selectivity of aspirin. Existing...

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Veröffentlicht in:J. Pharm. Sci.; (United States) 1985-02, Vol.74 (2), p.188-192
Hauptverfasser: Pedersen, Anders Kirstein, Fitzgerald, Garret A.
Format: Artikel
Sprache:eng
Schlagworte:
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
551001 - Physiological Systems- Tracer Techniques
ACETYLSALICYLIC ACID
ANALGESICS
ANIMALS
ANTIPYRETICS
Aspirin - blood
Aspirin - metabolism
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
BIOLOGICAL AVAILABILITY
BIOSYNTHESIS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL PREPARATION
Chromatography, High Pressure Liquid
Deuterium
DEUTERIUM COMPOUNDS
DOGS
DRUGS
Gas Chromatography-Mass Spectrometry
General pharmacology
Humans
HYDROGEN COMPOUNDS
HYDROXY ACIDS
Isotope Labeling - methods
KINETICS
Male
MAMMALS
Medical sciences
ORGANIC ACIDS
ORGANIC COMPOUNDS
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
PHARMACOLOGY
Pharmacology. Drug treatments
RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
SYNTHESIS
VERTEBRATES
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Zusammenfassung:Inhibition of endogenous prostacyclin and thromboxane biosynthesis by aspirin is critically dose-dependent in humans. Gastrointestinal and hepatic hydrolysis may limit systemic availability of aspirin, especially in low doses, perhaps contributing to the biochemical selectivity of aspirin. Existing analytical methods do not permit determination of systemic bioavailability when low (
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600740217