Antioxidant protection of Bio-normalizer in cerebral ischaemia-reperfusion injury in the gerbil

In this study we used cerebral ischaemia-reperfusion injury (IRI) as an experimental model to analyse the effects of Bio-normalizer (BN, a naturally fermented health food product) on reactive oxygen species related changes in different brain regions of gerbils. Pre-administration of BN solutions (0....

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Veröffentlicht in:	Neuroreport 1993-08, Vol.4 (8), p.1031-1034
Hauptverfasser:	Santiago, Librado A, Osato, James Akira, Ogawa, Norio, Mori, Akitane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Ischemia - metabolism Cardiovascular system Electron Spin Resonance Spectroscopy Fluorometry Free Radical Scavengers Gerbillinae Male Medical sciences Meriones unguiculatus Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal Reactive Oxygen Species - metabolism Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	In this study we used cerebral ischaemia-reperfusion injury (IRI) as an experimental model to analyse the effects of Bio-normalizer (BN, a naturally fermented health food product) on reactive oxygen species related changes in different brain regions of gerbils. Pre-administration of BN solutions (0.1% and 1%) for 45 days produced a significant reduction in IRI-mediated increase in membrane lipid peroxidation, as shown by the decreased carbon-centred radicals and thiobarbituric acid-reactive substances in several brain regions including the cerebral cortex, the hippocampus and the striatum. BN however has no effect on the mitochondrial superoxide dismutase activity.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-199308000-00009