The synthesis of alternating alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotic linkages as potential therapeutic agents

A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against...

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Veröffentlicht in:	Nucleic acids symposium series (1979) 1993 (29), p.3-4
Hauptverfasser:	Koga, M, Geyer, S J, Regan, J B, Beaucage, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Gene Products, tat - genetics Genes, tat HIV-1 - drug effects HIV-1 - genetics Molecular Sequence Data Nucleic Acid Denaturation Oligonucleotides, Antisense - chemical synthesis Oligonucleotides, Antisense - pharmacology tat Gene Products, Human Immunodeficiency Virus
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Zusammenfassung:	A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against HIV-1 tat mRNA, has been accomplished. Hybridization properties of these oligonucleotide analogues have been investigated.
ISSN:	0261-3166