In vitro evaluation of a continuous-sampling device for pharmacokinetic parameter estimation

Using an in vitro pharmacokinetic model, area under the curve (AUC) estimates from an osmotic continuous-withdrawal device were compared to AUC estimates by a conventional trapezoidal method. Ten experiments were done under two different conditions: (a) half-life of 1 h (n = 5) and (b) half-life of...

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Veröffentlicht in:	Therapeutic drug monitoring 1993-08, Vol.15 (4), p.294-299
Hauptverfasser:	PAAP, C. M, CHOCAS, E. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug Monitoring - instrumentation Evaluation Studies as Topic General pharmacology Half-Life Humans Medical sciences Methylene Blue - analysis Models, Biological Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Regression Analysis Software Specimen Handling - instrumentation
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