Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain

: This study investigated mitochondrial respiratory activity in Huntington's disease (HD) brain. Mitochondrial membranes from caudate and cortex of HD and non‐HD autopsied brains were assayed for succinate oxidation, cytochrome oxidase activity, and cytochromes b, cc1, and aa3. There was a sign...

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Veröffentlicht in:	Journal of neurochemistry 1985-06, Vol.44 (6), p.1948-1950
Hauptverfasser:	Brennan, William A., Bird, Edward D., Aprille, June R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brain - metabolism Brain mitochondria Cytochrome aa3 Cytochrome oxidase Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electron Transport Complex IV - analysis Humans Huntington Disease - genetics Huntington Disease - metabolism Huntington's disease In Vitro Techniques Medical sciences Mitochondria - metabolism Neurology Oxygen Consumption Respiratory activity
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Beschreibung
Zusammenfassung:	: This study investigated mitochondrial respiratory activity in Huntington's disease (HD) brain. Mitochondrial membranes from caudate and cortex of HD and non‐HD autopsied brains were assayed for succinate oxidation, cytochrome oxidase activity, and cytochromes b, cc1, and aa3. There was a significant decrease in HD caudate mitochondrial respiration, cytochrome oxidase activity, and cytochrome aa3, whereas cytochromes b and cc1 were normal. These findings are consistent with the hypothesis that mitochondrial dysfunction may contribute to the localized hypometabolism and progressive atrophy of the HD caudate.
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.1985.tb07192.x