Changes in the Mix of AIDS-Defining Conditions

To the Editor: Antiretroviral therapy and chemoprophylaxis are changing the natural history of infection with the human immunodeficiency virus (HIV), with a change in the pattern of initial AIDS-defining illnesses 1 , 2 [see Hoover et al. elsewhere in this issue]. In the U.S. military, HIV screening is mandatory. We reviewed the AIDS-defining diagnoses at the Naval Medical Center in San Diego, California, in patients who had been identified as HIV-seropositive or had received a diagnosis of AIDS while on active duty. A trend analysis was performed with a simple linear regression. AIDS was diagnosed in 198 patients during the period from . . .