Brain-derived neurotrophic factor expression after long-term potentiation

Brain-derived neurotrophic factor expression after long-term potentiation

Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N- methyl- d-aspartate (NMDA) antagonist dizocil...

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Veröffentlicht in:Neuroscience letters 1993-10, Vol.160 (2), p.232-236
Hauptverfasser: Dragunow, Michael, Beilharz, Erica, Mason, Betty, Lawlor, Patricia, Abraham, Wickliffe, Gluckman, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Animals
BDNF
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Brain-Derived Neurotrophic Factor
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Dizocilpine Maleate - pharmacology
Evoked Potentials - drug effects
Fundamental and applied biological sciences. Psychology
Gene Expression - drug effects
Growth factor
Hippocampus
In Situ Hybridization
Long-Term Potentiation - drug effects
LTP
Male
Memory
Nerve Growth Factors - biosynthesis
Nerve Tissue Proteins - biosynthesis
Rats
Rats, Sprague-Dawley
Retrograde messenger
RNA, Messenger - biosynthesis
Vertebrates: nervous system and sense organs
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Zusammenfassung:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N- methyl- d-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(93)90420-P