Clotting factors secreted by monocytes and macrophages: Analytical considerations
The secretion of clotting factors by rat spleen macrophages and human peripheral blood monocytes has been studied. The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin...
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| Veröffentlicht in: | Thrombosis research 1985, Vol.37 (1), p.9-19 |
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| container_title | Thrombosis research |
| container_volume | 37 |
| creator | van Dam-Mieras, Maria C.E. Muller, Annemarie D. van Deijk, Wijgert A. Hemker, H.Coenraad |
| description | The secretion of clotting factors by rat spleen macrophages and human peripheral blood monocytes has been studied. The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin in the culture medium is shown to decrease the vitamin K dependent clotting factor activity in the supernatant after in vitro culture of rat spleen macrophages and human peripheral blood monocytes. |
| doi_str_mv | 10.1016/0049-3848(85)90028-3 |
| format | Article |
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The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. 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The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin in the culture medium is shown to decrease the vitamin K dependent clotting factor activity in the supernatant after in vitro culture of rat spleen macrophages and human peripheral blood monocytes.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Factors - analysis</subject><subject>Cells, Cultured</subject><subject>clotting assays</subject><subject>clotting factors</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>macrophages</subject><subject>Macrophages - analysis</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>monocytes</subject><subject>Monocytes - analysis</subject><subject>Monocytes - metabolism</subject><subject>Platelet diseases and coagulopathies</subject><subject>Rats</subject><subject>Thrombin - pharmacology</subject><subject>Type C Phospholipases - pharmacology</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVJcZw0b5DAHkJpDpvOSlpLyqEQTNIGAqHQnIVWO3JUdleuJAf89pVr42NPMzDf_Px8hFw2cNtAs_gKwFXNJJdfZHujAKis2Qcyb6RQNeWCnpD5ETklZyn9BmhEo9oZmTElmQI-Jz-XQ8jZT6vKGZtDTFVCGzFjX3XbagxTsNuMqTJTX43GxrB-MytMd9X9ZIZt9tYMlQ1T8j1Gk33ZPpGPzgwJLw7znLw-Pvxa_qifX74_Le-fa8sZzXVHO8ucFQy4UUxKik6U5ky1pTSlzraw6FVrQHaMtRyt45wtWMcBBXUNsHPyeZ-7juHPBlPWo08Wh8FMGDZJiwUIoKotIN-DpX1KEZ1eRz-auNUN6J1JvdOkd5q0bPU_k5qVt6tD_qYbsT8-HdSV-_XhblKx4KKZrE9HTJUUJUTBvu0xLC7ePUadrMfJYu8j2qz74P_f4y8iOI7_</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>van Dam-Mieras, Maria C.E.</creator><creator>Muller, Annemarie D.</creator><creator>van Deijk, Wijgert A.</creator><creator>Hemker, H.Coenraad</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Clotting factors secreted by monocytes and macrophages: Analytical considerations</title><author>van Dam-Mieras, Maria C.E. ; Muller, Annemarie D. ; van Deijk, Wijgert A. ; Hemker, H.Coenraad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-b2bc3fc7304a93882ef787939500422fc506d95a08b3354ecf44363b40e72f103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Factors - analysis</topic><topic>Cells, Cultured</topic><topic>clotting assays</topic><topic>clotting factors</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>macrophages</topic><topic>Macrophages - analysis</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>monocytes</topic><topic>Monocytes - analysis</topic><topic>Monocytes - metabolism</topic><topic>Platelet diseases and coagulopathies</topic><topic>Rats</topic><topic>Thrombin - pharmacology</topic><topic>Type C Phospholipases - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Dam-Mieras, Maria C.E.</creatorcontrib><creatorcontrib>Muller, Annemarie D.</creatorcontrib><creatorcontrib>van Deijk, Wijgert A.</creatorcontrib><creatorcontrib>Hemker, H.Coenraad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Dam-Mieras, Maria C.E.</au><au>Muller, Annemarie D.</au><au>van Deijk, Wijgert A.</au><au>Hemker, H.Coenraad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clotting factors secreted by monocytes and macrophages: Analytical considerations</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1985</date><risdate>1985</risdate><volume>37</volume><issue>1</issue><spage>9</spage><epage>19</epage><pages>9-19</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>The secretion of clotting factors by rat spleen macrophages and human peripheral blood monocytes has been studied. The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin in the culture medium is shown to decrease the vitamin K dependent clotting factor activity in the supernatant after in vitro culture of rat spleen macrophages and human peripheral blood monocytes.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3983904</pmid><doi>10.1016/0049-3848(85)90028-3</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 1985, Vol.37 (1), p.9-19 |
| issn | 0049-3848 1879-2472 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76070295 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Blood Coagulation Factors - analysis Cells, Cultured clotting assays clotting factors Hematologic and hematopoietic diseases Humans macrophages Macrophages - analysis Macrophages - metabolism Medical sciences monocytes Monocytes - analysis Monocytes - metabolism Platelet diseases and coagulopathies Rats Thrombin - pharmacology Type C Phospholipases - pharmacology |
| title | Clotting factors secreted by monocytes and macrophages: Analytical considerations |
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