Clotting factors secreted by monocytes and macrophages: Analytical considerations

The secretion of clotting factors by rat spleen macrophages and human peripheral blood monocytes has been studied. The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin...

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Veröffentlicht in:	Thrombosis research 1985, Vol.37 (1), p.9-19
Hauptverfasser:	van Dam-Mieras, Maria C.E., Muller, Annemarie D., van Deijk, Wijgert A., Hemker, H.Coenraad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Coagulation Factors - analysis Cells, Cultured clotting assays clotting factors Hematologic and hematopoietic diseases Humans macrophages Macrophages - analysis Macrophages - metabolism Medical sciences monocytes Monocytes - analysis Monocytes - metabolism Platelet diseases and coagulopathies Rats Thrombin - pharmacology Type C Phospholipases - pharmacology
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Beschreibung
Zusammenfassung:	The secretion of clotting factors by rat spleen macrophages and human peripheral blood monocytes has been studied. The results show that the amount of clotting factors measured depends critically upon the characteristics of the assay system used. The presence of warfarin, salicylic acid or thrombin in the culture medium is shown to decrease the vitamin K dependent clotting factor activity in the supernatant after in vitro culture of rat spleen macrophages and human peripheral blood monocytes.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(85)90028-3