Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells
The effects of 2-deoxy-D-glucose (2-DG) on energy metabolism, cell proliferation kinetics, radiation-induced DNA repair, and micronuclei formation in HeLa cells have been studied. Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations...
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| Veröffentlicht in: | Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1985-05, Vol.11 (5), p.943-950 |
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| container_title | Int. J. Radiat. Oncol., Biol. Phys.; (United States) |
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| creator | Jain, V.K. Kalia, V.K. Sharma, R. Maharajan, V. Menon, M. |
| description | The effects of 2-deoxy-D-glucose (2-DG) on energy metabolism, cell proliferation kinetics, radiation-induced DNA repair, and micronuclei formation in HeLa cells have been studied. Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations (>2.5 mM), DNA repair is inhibited and manifestation of radiation damage is enhanced as observed by an increase in the radiation (X ray) induced micronuclei formation; (2) lower concentrations of 2-DG ( |
| doi_str_mv | 10.1016/0360-3016(85)90117-8 |
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Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations (>2.5 mM), DNA repair is inhibited and manifestation of radiation damage is enhanced as observed by an increase in the radiation (X ray) induced micronuclei formation; (2) lower concentrations of 2-DG (<2.5 mM) do not inhibit DNA repair and a decrease in the frequency of micronuclei formation is observed. These data, in correlation with the effects of 2-DG on glycolysis and cell proliferation kinetics, can be explained by the hypothesis that 2-DG induced modifications of radiation effects arise as a result of energy linked differential inhibitions of pathways of repair andfixation of DNA damage. Implications for cancer therapy are discussed.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(85)90117-8</identifier><identifier>PMID: 3988563</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>2-deoxy-D-glucose ; 560121 - Radiation Effects on Cells- External Source- (-1987) ; ALDEHYDES ; ANIMAL CELLS ; ANIMALS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BIOLOGICAL RECOVERY ; BIOLOGICAL REPAIR ; Cancer therapy ; CARBOHYDRATES ; Cell Division - drug effects ; Cell Division - radiation effects ; Cell kinetics ; Cell Nucleus - drug effects ; Cell Nucleus - radiation effects ; Cell Nucleus - ultrastructure ; CELL PROLIFERATION ; CHEMICAL REACTIONS ; COBALT 60 ; COBALT ISOTOPES ; DATA ; DECOMPOSITION ; Deoxy Sugars - pharmacology ; Deoxyglucose - pharmacology ; DNA REPAIR ; ELECTROMAGNETIC RADIATION ; Energy Metabolism ; EXPERIMENTAL DATA ; Flow Cytometry ; GAMMA RADIATION ; Gamma Rays ; General aspects (metabolism, cell proliferation, established cell line...) ; GLUCOSE ; GLYCOLYSIS ; Glycolysis - drug effects ; HELA CELLS ; HEXOSES ; Humans ; INFORMATION ; INTERMEDIATE MASS NUCLEI ; INTERNAL CONVERSION RADIOISOTOPES ; Interphase - drug effects ; Interphase - radiation effects ; IONIZING RADIATIONS ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; KINETICS ; MAMMALS ; MAN ; Medical sciences ; Micronuclei ; MINUTES LIVING RADIOISOTOPES ; MONOSACCHARIDES ; NUCLEI ; NUMERICAL DATA ; ODD-ODD NUCLEI ; ORGANIC COMPOUNDS ; PRIMATES ; RADIATION EFFECTS ; Radiation response ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOINDUCTION ; RADIOISOTOPES ; RADIOSENSITIVITY EFFECTS ; RECOVERY ; REPAIR ; SACCHARIDES ; Tumor cell ; TUMOR CELLS ; Tumors ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1985-05, Vol.11 (5), p.943-950</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-394730ce442e055d837c7820ef35d41779650c3c1845f84c75ac05cc0df5165e3</citedby><cites>FETCH-LOGICAL-c479t-394730ce442e055d837c7820ef35d41779650c3c1845f84c75ac05cc0df5165e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0360-3016(85)90117-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8500798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3988563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5302470$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, V.K.</creatorcontrib><creatorcontrib>Kalia, V.K.</creatorcontrib><creatorcontrib>Sharma, R.</creatorcontrib><creatorcontrib>Maharajan, V.</creatorcontrib><creatorcontrib>Menon, M.</creatorcontrib><creatorcontrib>National Institute of Mental Health and Neuro Sciences, Bangalore, India</creatorcontrib><title>Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells</title><title>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>The effects of 2-deoxy-D-glucose (2-DG) on energy metabolism, cell proliferation kinetics, radiation-induced DNA repair, and micronuclei formation in HeLa cells have been studied. Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations (>2.5 mM), DNA repair is inhibited and manifestation of radiation damage is enhanced as observed by an increase in the radiation (X ray) induced micronuclei formation; (2) lower concentrations of 2-DG (<2.5 mM) do not inhibit DNA repair and a decrease in the frequency of micronuclei formation is observed. These data, in correlation with the effects of 2-DG on glycolysis and cell proliferation kinetics, can be explained by the hypothesis that 2-DG induced modifications of radiation effects arise as a result of energy linked differential inhibitions of pathways of repair andfixation of DNA damage. Implications for cancer therapy are discussed.</description><subject>2-deoxy-D-glucose</subject><subject>560121 - Radiation Effects on Cells- External Source- (-1987)</subject><subject>ALDEHYDES</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BIOLOGICAL RECOVERY</subject><subject>BIOLOGICAL REPAIR</subject><subject>Cancer therapy</subject><subject>CARBOHYDRATES</subject><subject>Cell Division - drug effects</subject><subject>Cell Division - radiation effects</subject><subject>Cell kinetics</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - radiation effects</subject><subject>Cell Nucleus - ultrastructure</subject><subject>CELL PROLIFERATION</subject><subject>CHEMICAL REACTIONS</subject><subject>COBALT 60</subject><subject>COBALT ISOTOPES</subject><subject>DATA</subject><subject>DECOMPOSITION</subject><subject>Deoxy Sugars - pharmacology</subject><subject>Deoxyglucose - pharmacology</subject><subject>DNA REPAIR</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>Energy Metabolism</subject><subject>EXPERIMENTAL DATA</subject><subject>Flow Cytometry</subject><subject>GAMMA RADIATION</subject><subject>Gamma Rays</subject><subject>General aspects (metabolism, cell proliferation, established cell line...)</subject><subject>GLUCOSE</subject><subject>GLYCOLYSIS</subject><subject>Glycolysis - drug effects</subject><subject>HELA CELLS</subject><subject>HEXOSES</subject><subject>Humans</subject><subject>INFORMATION</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL CONVERSION RADIOISOTOPES</subject><subject>Interphase - drug effects</subject><subject>Interphase - radiation effects</subject><subject>IONIZING RADIATIONS</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>KINETICS</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Medical sciences</subject><subject>Micronuclei</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>MONOSACCHARIDES</subject><subject>NUCLEI</subject><subject>NUMERICAL DATA</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>PRIMATES</subject><subject>RADIATION EFFECTS</subject><subject>Radiation response</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOINDUCTION</subject><subject>RADIOISOTOPES</subject><subject>RADIOSENSITIVITY EFFECTS</subject><subject>RECOVERY</subject><subject>REPAIR</subject><subject>SACCHARIDES</subject><subject>Tumor cell</subject><subject>TUMOR CELLS</subject><subject>Tumors</subject><subject>VERTEBRATES</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-LFDEQxYMo67j6DRSCiCjYmnSSTvoiyLr-gQUvCt5CrK7sRns6s6lucb69aWeYo6cUeb8q6r1i7LEUr6WQ3RuhOtGoWr1w5mUvpLSNu8M20tm-UcZ8v8s2J-Q-e0D0U4iV0mfsTPXOmU5tWL6MEWEmniNvmwHzn33zvrkeF8iEPE_8etxDHveU6BXflTymiCXMqSq_0oRzAuJhGngJQzp8F6RdntbmyG-WbZg4hAmwcMBxpIfsXgwj4aPje86-fbj8evGpufry8fPFu6sGtO3nRvXaKgGodYvCmMEpC9a1AqMyg5bW9p0RoEA6baLTYE0AYQDEEI3sDKpz9vQwN9OcPEGaEW4gT1M1640SrbaiQs8PUDV2uyDNfptoXTNMmBfythOdcV1bQX0AoWSigtHvStqGsvdS-PUYfk3ar0l7Z_y_Y3hX254c5y8_tjicmo7pV_3ZUQ8EYYylBpXohDkjhO3XMW8PGNbAficsqx-smQ6prHaGnP6_x1-bqqT0</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Jain, V.K.</creator><creator>Kalia, V.K.</creator><creator>Sharma, R.</creator><creator>Maharajan, V.</creator><creator>Menon, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198505</creationdate><title>Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells</title><author>Jain, V.K. ; Kalia, V.K. ; Sharma, R. ; Maharajan, V. ; Menon, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-394730ce442e055d837c7820ef35d41779650c3c1845f84c75ac05cc0df5165e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>2-deoxy-D-glucose</topic><topic>560121 - Radiation Effects on Cells- External Source- (-1987)</topic><topic>ALDEHYDES</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BIOLOGICAL RECOVERY</topic><topic>BIOLOGICAL REPAIR</topic><topic>Cancer therapy</topic><topic>CARBOHYDRATES</topic><topic>Cell Division - drug effects</topic><topic>Cell Division - radiation effects</topic><topic>Cell kinetics</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - radiation effects</topic><topic>Cell Nucleus - ultrastructure</topic><topic>CELL PROLIFERATION</topic><topic>CHEMICAL REACTIONS</topic><topic>COBALT 60</topic><topic>COBALT ISOTOPES</topic><topic>DATA</topic><topic>DECOMPOSITION</topic><topic>Deoxy Sugars - pharmacology</topic><topic>Deoxyglucose - pharmacology</topic><topic>DNA REPAIR</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>Energy Metabolism</topic><topic>EXPERIMENTAL DATA</topic><topic>Flow Cytometry</topic><topic>GAMMA RADIATION</topic><topic>Gamma Rays</topic><topic>General aspects (metabolism, cell proliferation, established cell line...)</topic><topic>GLUCOSE</topic><topic>GLYCOLYSIS</topic><topic>Glycolysis - drug effects</topic><topic>HELA CELLS</topic><topic>HEXOSES</topic><topic>Humans</topic><topic>INFORMATION</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL CONVERSION RADIOISOTOPES</topic><topic>Interphase - drug effects</topic><topic>Interphase - radiation effects</topic><topic>IONIZING RADIATIONS</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>KINETICS</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Medical sciences</topic><topic>Micronuclei</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>MONOSACCHARIDES</topic><topic>NUCLEI</topic><topic>NUMERICAL DATA</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>PRIMATES</topic><topic>RADIATION EFFECTS</topic><topic>Radiation response</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOINDUCTION</topic><topic>RADIOISOTOPES</topic><topic>RADIOSENSITIVITY EFFECTS</topic><topic>RECOVERY</topic><topic>REPAIR</topic><topic>SACCHARIDES</topic><topic>Tumor cell</topic><topic>TUMOR CELLS</topic><topic>Tumors</topic><topic>VERTEBRATES</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, V.K.</creatorcontrib><creatorcontrib>Kalia, V.K.</creatorcontrib><creatorcontrib>Sharma, R.</creatorcontrib><creatorcontrib>Maharajan, V.</creatorcontrib><creatorcontrib>Menon, M.</creatorcontrib><creatorcontrib>National Institute of Mental Health and Neuro Sciences, Bangalore, India</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, V.K.</au><au>Kalia, V.K.</au><au>Sharma, R.</au><au>Maharajan, V.</au><au>Menon, M.</au><aucorp>National Institute of Mental Health and Neuro Sciences, Bangalore, India</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells</atitle><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1985-05</date><risdate>1985</risdate><volume>11</volume><issue>5</issue><spage>943</spage><epage>950</epage><pages>943-950</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>The effects of 2-deoxy-D-glucose (2-DG) on energy metabolism, cell proliferation kinetics, radiation-induced DNA repair, and micronuclei formation in HeLa cells have been studied. Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations (>2.5 mM), DNA repair is inhibited and manifestation of radiation damage is enhanced as observed by an increase in the radiation (X ray) induced micronuclei formation; (2) lower concentrations of 2-DG (<2.5 mM) do not inhibit DNA repair and a decrease in the frequency of micronuclei formation is observed. These data, in correlation with the effects of 2-DG on glycolysis and cell proliferation kinetics, can be explained by the hypothesis that 2-DG induced modifications of radiation effects arise as a result of energy linked differential inhibitions of pathways of repair andfixation of DNA damage. Implications for cancer therapy are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3988563</pmid><doi>10.1016/0360-3016(85)90117-8</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1985-05, Vol.11 (5), p.943-950 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| subjects | 2-deoxy-D-glucose 560121 - Radiation Effects on Cells- External Source- (-1987) ALDEHYDES ANIMAL CELLS ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOLOGICAL RECOVERY BIOLOGICAL REPAIR Cancer therapy CARBOHYDRATES Cell Division - drug effects Cell Division - radiation effects Cell kinetics Cell Nucleus - drug effects Cell Nucleus - radiation effects Cell Nucleus - ultrastructure CELL PROLIFERATION CHEMICAL REACTIONS COBALT 60 COBALT ISOTOPES DATA DECOMPOSITION Deoxy Sugars - pharmacology Deoxyglucose - pharmacology DNA REPAIR ELECTROMAGNETIC RADIATION Energy Metabolism EXPERIMENTAL DATA Flow Cytometry GAMMA RADIATION Gamma Rays General aspects (metabolism, cell proliferation, established cell line...) GLUCOSE GLYCOLYSIS Glycolysis - drug effects HELA CELLS HEXOSES Humans INFORMATION INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES Interphase - drug effects Interphase - radiation effects IONIZING RADIATIONS ISOMERIC TRANSITION ISOTOPES ISOTOPES KINETICS MAMMALS MAN Medical sciences Micronuclei MINUTES LIVING RADIOISOTOPES MONOSACCHARIDES NUCLEI NUMERICAL DATA ODD-ODD NUCLEI ORGANIC COMPOUNDS PRIMATES RADIATION EFFECTS Radiation response RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RADIOISOTOPES RADIOSENSITIVITY EFFECTS RECOVERY REPAIR SACCHARIDES Tumor cell TUMOR CELLS Tumors VERTEBRATES YEARS LIVING RADIOISOTOPES |
| title | Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells |
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