Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells

The effects of 2-deoxy-D-glucose (2-DG) on energy metabolism, cell proliferation kinetics, radiation-induced DNA repair, and micronuclei formation in HeLa cells have been studied. Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations...

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Veröffentlicht in:	Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1985-05, Vol.11 (5), p.943-950
Hauptverfasser:	Jain, V.K., Kalia, V.K., Sharma, R., Maharajan, V., Menon, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-deoxy-D-glucose 560121 - Radiation Effects on Cells- External Source- (-1987) ALDEHYDES ANIMAL CELLS ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOLOGICAL RECOVERY BIOLOGICAL REPAIR Cancer therapy CARBOHYDRATES Cell Division - drug effects Cell Division - radiation effects Cell kinetics Cell Nucleus - drug effects Cell Nucleus - radiation effects Cell Nucleus - ultrastructure CELL PROLIFERATION CHEMICAL REACTIONS COBALT 60 COBALT ISOTOPES DATA DECOMPOSITION Deoxy Sugars - pharmacology Deoxyglucose - pharmacology DNA REPAIR ELECTROMAGNETIC RADIATION Energy Metabolism EXPERIMENTAL DATA Flow Cytometry GAMMA RADIATION Gamma Rays General aspects (metabolism, cell proliferation, established cell line...) GLUCOSE GLYCOLYSIS Glycolysis - drug effects HELA CELLS HEXOSES Humans INFORMATION INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES Interphase - drug effects Interphase - radiation effects IONIZING RADIATIONS ISOMERIC TRANSITION ISOTOPES ISOTOPES KINETICS MAMMALS MAN Medical sciences Micronuclei MINUTES LIVING RADIOISOTOPES MONOSACCHARIDES NUCLEI NUMERICAL DATA ODD-ODD NUCLEI ORGANIC COMPOUNDS PRIMATES RADIATION EFFECTS Radiation response RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RADIOISOTOPES RADIOSENSITIVITY EFFECTS RECOVERY REPAIR SACCHARIDES Tumor cell TUMOR CELLS Tumors VERTEBRATES YEARS LIVING RADIOISOTOPES
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Zusammenfassung:	The effects of 2-deoxy-D-glucose (2-DG) on energy metabolism, cell proliferation kinetics, radiation-induced DNA repair, and micronuclei formation in HeLa cells have been studied. Results show that the 2-DG induced modifications of the radiation effects are biphasic: (1) at high 2-DG conceentrations (>2.5 mM), DNA repair is inhibited and manifestation of radiation damage is enhanced as observed by an increase in the radiation (X ray) induced micronuclei formation; (2) lower concentrations of 2-DG (
ISSN:	0360-3016 1879-355X
DOI:	10.1016/0360-3016(85)90117-8