Vigabatrin in the Treatment of Infantile Spasms

Abstract The anti-epileptic effect of vigabatrin as a first choice therapy was investigated in 6 children suffering from infantile spasms (IS). All 6 children showed a reduction in seizure frequency. Three children became seizure-free within a period of 2 weeks. Because our results suggest "an...

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Veröffentlicht in:	Neuropediatrics 1993-08, Vol.24 (4), p.230-231
Hauptverfasser:	Vles, J. S. H., van der Heyden, A. M. H. G., Ghijs, A., Troost, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminocaproates - therapeutic use Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Electroencephalography - drug effects Female Humans Infant Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Short communication Spasms, Infantile - drug therapy Spasms, Infantile - etiology Spasms, Infantile - physiopathology Vigabatrin
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Zusammenfassung:	Abstract The anti-epileptic effect of vigabatrin as a first choice therapy was investigated in 6 children suffering from infantile spasms (IS). All 6 children showed a reduction in seizure frequency. Three children became seizure-free within a period of 2 weeks. Because our results suggest "an all or nothing phenomenon", a period of 2 weeks may be sufficient to evaluate the efficacy of vigabatrin in untreated infants suffering from IS. We suggest to use vigabatrin as a first choice anti-epileptic drug in infants with IS.
ISSN:	0174-304X 1439-1899
DOI:	10.1055/s-2008-1071546