In vitro infection of bovine brain endothelial cells by Cowdria ruminantium

Endothelial cells from bovine brain capillaries ( BBEC) were successfully infected with the Gardel stock of Cowdria ruminantium. Growth conditions of cowdria in BBEC and bovine umbilical endothelial cells ( BUE) were identical with average intervals between passages of 8·6 and 8·9 days in BBEC (17 p...

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Veröffentlicht in:	Research in veterinary science 1993-09, Vol.55 (2), p.258-260
Hauptverfasser:	Martinez, D., Sheikboudou, C., Couraud, P.O., Bensaid, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Blood-Brain Barrier Brain - blood supply Capillaries Cattle Cell Division - radiation effects Cells, Cultured Ehrlichia ruminantium - growth & development Ehrlichia ruminantium - pathogenicity Endothelium, Vascular - cytology Endothelium, Vascular - microbiology Fundamental and applied biological sciences. Psychology Gamma Rays Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Umbilical Veins
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Zusammenfassung:	Endothelial cells from bovine brain capillaries ( BBEC) were successfully infected with the Gardel stock of Cowdria ruminantium. Growth conditions of cowdria in BBEC and bovine umbilical endothelial cells ( BUE) were identical with average intervals between passages of 8·6 and 8·9 days in BBEC (17 passages) and BUE (28 passages), respectively. The time required to complete the life cycle and the morphology of the parasite were identical in both types of cells. The demonstration that BBEC may be infected with C ruminantium offers the means to study the mechanism of infection of the blood brain barrier endothelium by this parasite.
ISSN:	0034-5288 1532-2661
DOI:	10.1016/0034-5288(93)90090-3