Cyclosporin A, FK506 and rapamycin: more than just immunosuppression
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinosit...
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| Veröffentlicht in: | Trends in Biochemical Sciences 1993-09, Vol.18 (9), p.334-338 |
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| container_title | Trends in Biochemical Sciences |
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| creator | Kunz, Jeannette Hall, Michael N. |
| description | The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex. |
| doi_str_mv | 10.1016/0968-0004(93)90069-Y |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Trends in Biochemical Sciences, 1993-09, Vol.18 (9), p.334-338 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Isomerases - metabolism Amino Acid Sequence Calcineurin Calmodulin-Binding Proteins - metabolism Carrier Proteins - metabolism Consensus Sequence Cyclosporine - pharmacology Immunosuppressive Agents - pharmacology Molecular Sequence Data Peptidylprolyl Isomerase Phosphatidylinositol 3-Kinases Phosphoprotein Phosphatases - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Polyenes - pharmacology Saccharomyces cerevisiae - drug effects Signal Transduction - drug effects Sirolimus Tacrolimus - pharmacology |
| title | Cyclosporin A, FK506 and rapamycin: more than just immunosuppression |
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