Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinosit...

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Veröffentlicht in:	Trends in Biochemical Sciences 1993-09, Vol.18 (9), p.334-338
Hauptverfasser:	Kunz, Jeannette, Hall, Michael N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Isomerases - metabolism Amino Acid Sequence Calcineurin Calmodulin-Binding Proteins - metabolism Carrier Proteins - metabolism Consensus Sequence Cyclosporine - pharmacology Immunosuppressive Agents - pharmacology Molecular Sequence Data Peptidylprolyl Isomerase Phosphatidylinositol 3-Kinases Phosphoprotein Phosphatases - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Polyenes - pharmacology Saccharomyces cerevisiae - drug effects Signal Transduction - drug effects Sirolimus Tacrolimus - pharmacology
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Zusammenfassung:	The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/0968-0004(93)90069-Y