Comparative effect of synthetic aminoestrogens with estradiol on platelet aggregation

The in vitro effect upon platelet aggregation of estradiol and synthetic estrogens (prolame, buame, and proacame) is described. Prolame and buame produced a dose-dependent inhibition on platelet aggregation. Estradiol and proacame did not show anti-aggregating effects. The results suggest that the u...

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Veröffentlicht in:	Steroids 1993-09, Vol.58 (9), p.407-409
Hauptverfasser:	De la Peña, Aurora, Baños, Guadalupe, Izaguirre, Raúl, Mandoki, Juan J., Fernández-G, Juan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult aminoestrogens Biological and medical sciences buame estradiol Estradiol - pharmacology Estradiol Congeners - pharmacology Estranes - pharmacology Estrenes - pharmacology Hormones. Endocrine system Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology proacame prolame
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Zusammenfassung:	The in vitro effect upon platelet aggregation of estradiol and synthetic estrogens (prolame, buame, and proacame) is described. Prolame and buame produced a dose-dependent inhibition on platelet aggregation. Estradiol and proacame did not show anti-aggregating effects. The results suggest that the use of prolame and buame in estrogen therapy could reduce the risk of thrombo-embolic accidents.
ISSN:	0039-128X 1878-5867
DOI:	10.1016/0039-128X(93)90079-3