Impairment of opioid control of luteinizing hormone secretion in menstrual disorders

With the aim of examining central opioid influences on the control of luteinizing hormone (LH) secretion, we evaluated the LH response to naloxone, an opioid receptor antagonist, in patients affected by normo-, hyper-, and hypogonadotropic amenorrhea, polycystic ovarian disease and hyperprolactinemi...

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Veröffentlicht in:	Fertility and sterility 1985-04, Vol.43 (4), p.534-540
Hauptverfasser:	Petraglia, Felice, D’Ambrogio, Gerardo, Comitini, Giuseppina, Facchinetti, Fabio, Volpe, Annibale, Genazzani, Andrea R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Adolescent Adult Amenorrhea - metabolism Biological and medical sciences Body Weight Female Female genital diseases Gonadotropin-Releasing Hormone - pharmacology Gonadotropin-Releasing Hormone - physiology Gynecology. Andrology. Obstetrics Humans Hypothalamo-Hypophyseal System - physiopathology Luteinizing Hormone - blood Luteinizing Hormone - metabolism Medical sciences Menstruation Disturbances - metabolism Naloxone - pharmacology Naloxone - physiology Non tumoral diseases Oligomenorrhea - metabolism Ovary - physiopathology Pituitary Neoplasms - metabolism Prolactin - metabolism
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Zusammenfassung:	With the aim of examining central opioid influences on the control of luteinizing hormone (LH) secretion, we evaluated the LH response to naloxone, an opioid receptor antagonist, in patients affected by normo-, hyper-, and hypogonadotropic amenorrhea, polycystic ovarian disease and hyperprolactinemia. The results indicate that opioid influences are altered in well-defined pathologic conditions (hyperprolactinemia, obesity), in addition to being modified by gonadal steroids.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/S0015-0282(16)48493-1