In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography

In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using[11C]dimethyloxazolidinedione ([11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rp...

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Veröffentlicht in:	Annals of neurology 1985-01, Vol.17 (1), p.70-79
Hauptverfasser:	Rottenberg, D. A., Ginos, J. Z., Kearfott, K. G., Junck, L., Dhawan, V., Jarden, J. O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain Neoplasms - diagnostic imaging Brain Neoplasms - metabolism Carbon Radioisotopes Dimethadione Female Humans Hydrogen-Ion Concentration Male Medical sciences Middle Aged Neurology Oxazoles Tomography, Emission-Computed Tumors of the nervous system. Phacomatoses
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Zusammenfassung:	In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using[11C]dimethyloxazolidinedione ([11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter.
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.410170116