Effect of crude coal tar in the mouse-tail model of psoriasis

A histological comparison was made between normal mouse tails and those treated with crude coal tar, and the effect of crude coal tar on the keratin profile of the living cells of treated animals was examined. The prophylactic effect of crude coal tar on the neonatal mouse tail is described. The var...

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Veröffentlicht in:	Archives of Dermatological Research 1985, Vol.277 (2), p.121-125
Hauptverfasser:	BLADON, P. T, TAYLOR, M, WOOD, E. J, CUNLIFFE, W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Coal Tar - pharmacology Disease Models, Animal Keratins - analysis Keratins - isolation & purification Male Medical sciences Mice Mice, Inbred Strains Molecular Weight Pharmacology. Drug treatments Protein Precursors - isolation & purification Psoriasis - pathology Skin - cytology Skin - drug effects Skin - pathology Skin, nail, hair, dermoskeleton
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Zusammenfassung:	A histological comparison was made between normal mouse tails and those treated with crude coal tar, and the effect of crude coal tar on the keratin profile of the living cells of treated animals was examined. The prophylactic effect of crude coal tar on the neonatal mouse tail is described. The variation in the anatomical site of prekeratin of the dorsal and tail epidermis of the mouse is reported. These results are discussed with reference to the use of the mouse tail as a model for screening drugs for the treatment of psoriasis.
ISSN:	0340-3696 1432-069X
DOI:	10.1007/BF00414109