The GABA-ergic system: a locus of benzodiazepine action

gamma -Aminobutyric acid is regarded as one of the major inhibitory amino acid transmitters in the mammalian brain. In most regions of the brain, GABA is associated with local inhibitory neurons and only in two regions is GABA associated with longer projections. The present article describes how int...

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Veröffentlicht in:	Annual review of neuroscience 1985-01, Vol.8 (1), p.21-44
Hauptverfasser:	TALIMAN, J. F, GALLAGER, D. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - metabolism Anti-Anxiety Agents - pharmacology Benzodiazepines Biological and medical sciences brain Brain - drug effects Brain - metabolism Brain Chemistry Carbolines - pharmacology Chemical Phenomena Chemistry gamma -aminobutyric acid gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - physiology Humans Mammalia Medical sciences Molecular Conformation Neuropharmacology Pharmacology. Drug treatments Picrotoxin - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Receptors, GABA-A - analysis Receptors, GABA-A - drug effects Receptors, GABA-A - physiology reviews Synaptic Transmission
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Zusammenfassung:	gamma -Aminobutyric acid is regarded as one of the major inhibitory amino acid transmitters in the mammalian brain. In most regions of the brain, GABA is associated with local inhibitory neurons and only in two regions is GABA associated with longer projections. The present article describes how interaction of binding sites for GABA, benzodiazepines (BDZ), and chloride channel blockers (picrotoxin, TBPS) results in the pharmacological activities of these compounds.
ISSN:	0147-006X 1545-4126
DOI:	10.1146/annurev.ne.08.030185.000321