GABA control of LHRH release is dependent on the steroid milieu

The effect of GABA in controlling luteinizing hormone releasing hormone (LHRH) release from isolated hypothalamic fragments containing the mediobasal hypothalamus, suprachiasmatic nucleus, and the preoptic area (MBH-SCN-POA) was tested under different hormonal conditions with an in vitro superfusion...

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Veröffentlicht in:	Neuroscience letters 1993-07, Vol.157 (2), p.227-230
Hauptverfasser:	McRee, R.Carter, Meyer, Donald C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Estradiol Estradiol - pharmacology Estrus - physiology Feedback Female Fundamental and applied biological sciences. Psychology GABA gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - physiology Gonadotropin-Releasing Hormone - metabolism Hormones and neuropeptides. Regulation Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Luteinizing hormone releasing hormone Mediobasal hypothalamus Muscimol Muscimol - pharmacology Ovariectomy Ovulation - physiology Preoptic Area - drug effects Preoptic Area - metabolism Proestrus Rats Secretory Rate - drug effects Vertebrates: endocrinology
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Zusammenfassung:	The effect of GABA in controlling luteinizing hormone releasing hormone (LHRH) release from isolated hypothalamic fragments containing the mediobasal hypothalamus, suprachiasmatic nucleus, and the preoptic area (MBH-SCN-POA) was tested under different hormonal conditions with an in vitro superfusion method. GABA significantly decreased LHRH release under conditions of low, chronic levels of estradiol (E 2) treatment but had no effect on tissue obtained from animals in proestrus. This suggests that the inhibitory effect of GABA is only manifested during certain stages of the estrous cycle characterized by negative feedback and low E 2.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(93)90743-5