Hippocampal mossy fiber changes in mice transgenic for the human copper-zinc superoxide dismutase gene

Hippocampal mossy fiber changes in mice transgenic for the human copper-zinc superoxide dismutase gene

The copper-zinc superoxide dismutase (SOD-1) gene, located on chromosome 21 and triplicated in Down's syndrome (DS), is suspected to be involved in the neuropathology observed in Alzheimer's disease (AD), DS and physiological aging. In order to explore the effect of an overproduction of SO...

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Veröffentlicht in:Neuroscience letters 1993-09, Vol.160 (1), p.24-28
Hauptverfasser: Barkats, M., Bertholet, J.-Y., Venault, P., Ceballos-Picot, I., Nicole, A., Phillips, J., Moutier, R., Roubertoux, P., Sinet, P.-M., Cohen-Salmon, C.
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Axons - enzymology
Biological and medical sciences
Copper-zinc superoxide dismutase
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Free radical
Free Radicals - metabolism
Hippocampus
Hippocampus - anatomy & histology
Hippocampus - cytology
Hippocampus - enzymology
Humans
Male
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Transgenic
Mossy fiber
Nerve Fibers - enzymology
Neurology
Superoxide Dismutase - biosynthesis
Superoxide Dismutase - genetics
Transgenic mouse
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Zusammenfassung:The copper-zinc superoxide dismutase (SOD-1) gene, located on chromosome 21 and triplicated in Down's syndrome (DS), is suspected to be involved in the neuropathology observed in Alzheimer's disease (AD), DS and physiological aging. In order to explore the effect of an overproduction of SOD-1 in the mouse hippocampus, we investigated the Timm-stained mossy fiber (MF) innervation in the hippocampus of transgenic mice for the human SOD-1 gene (hSOD-1 mice). The results showed a decrease of the MF projection area in the hSOD-1 mice overexpressing the SOD-1 protein. These findings suggest that free radicals could play a role in this particular synaptic loss.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(93)90908-4