Philadelphia-positive T-acute lymphoblastic leukemia

A case of typical T-acute lymphoblastic leukemia (T-ALL) is reported in which, at diagnosis, 100% of bone marrow metaphases showed a Philadelphia (Ph) translocation, t(9;22). These cells completely disappeared following chemotherapy. The significance of the Ph chromosome in T and B leukemic cells is...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1985-04, Vol.16 (4), p.297-300
Hauptverfasser:	Louwagie, Andries, Criel, Arnold, Verfaillie, C.M., Valcke, Y.J., Lamberts, H., Hidajat, M., Mecucci, Cristina, Van Den Berghe, Herman
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Hematologic and hematopoietic diseases Humans Leukemia, Lymphoid - drug therapy Leukemia, Lymphoid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged T-Lymphocytes Translocation, Genetic
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Zusammenfassung:	A case of typical T-acute lymphoblastic leukemia (T-ALL) is reported in which, at diagnosis, 100% of bone marrow metaphases showed a Philadelphia (Ph) translocation, t(9;22). These cells completely disappeared following chemotherapy. The significance of the Ph chromosome in T and B leukemic cells is discussed.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(85)90236-5