Impaired Phagolysosomal Fusion of Peripheral Blood Monocytes from HIV‐Infected Subjects

Impaired Phagolysosomal Fusion of Peripheral Blood Monocytes from HIV‐Infected Subjects

We evaluated phagolysosomal fusion in peripheral blood monocytes from 20 HIV‐infected individuals and 40 normal controls, using a fluorescence assay with acridine orange as marker. The percentages of phagolysosomal fusion of monocytes from HIV‐infected subjects, after 30 and 60 min of yeast ingestio...

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Veröffentlicht in:Scandinavian journal of immunology 1993-11, Vol.38 (5), p.423-427
Hauptverfasser: PITTIS, M. G., STERNIK, G., SEN, L., DIEZ, R. A., PLANES, N., PIROLA, D., ESTEVEZ, M. E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
AIDS/HIV
Biological and medical sciences
CD4-CD8 Ratio
Cell Fusion
Female
HIV Envelope Protein gp120 - pharmacology
HIV Infections - blood
HIV Infections - pathology
HIV-1
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Lysosomes - pathology
Lysosomes - physiology
Male
Medical sciences
Middle Aged
Monocytes - physiology
Phagocytosis
Phagosomes - pathology
Phagosomes - physiology
Recombinant Proteins - pharmacology
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Zusammenfassung:We evaluated phagolysosomal fusion in peripheral blood monocytes from 20 HIV‐infected individuals and 40 normal controls, using a fluorescence assay with acridine orange as marker. The percentages of phagolysosomal fusion of monocytes from HIV‐infected subjects, after 30 and 60 min of yeast ingestion, (mean ± standard deviation) 57·2 ± 17 and 63·2 ± 18·6, respectively, when compared to normal controls (72·4 ± 7·8 and 77 ± 8·1), did not differ significantly. However, there was a direct linear association between the percentages of phagolysosomal fusion and CD4+ lymphocytes (P
ISSN:0300-9475
1365-3083
DOI:10.1111/j.1365-3083.1993.tb02583.x