GABAergic control of the cholinergic projections to the frontal cortex is not tonic

The turnover rate of acetylcholine was measured in the frontal cortex of rats after either microinjection of bicuculline into the substantia inominata (the source of the cortical cholinergic innervation) or kainic acid lesioning of the nucleus accumbens (the source of GABAergic innervation of the su...

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Veröffentlicht in:	Brain research 1985-01, Vol.325 (1), p.389-390
1. Verfasser:	Blaker, William D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal Ganglia - physiology Bicuculline - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cholinergic Fibers - physiology frontal cortex Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - physiology Kainic Acid - pharmacology Male nucleus accumbens Nucleus Accumbens - physiology Rats Rats, Inbred Strains Septal Nuclei - physiology Substantia Innominata - physiology substantia inominata turnover rate of acetylcholine Vertebrates: nervous system and sense organs γ-aminobutyric acid (GABA)
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Zusammenfassung:	The turnover rate of acetylcholine was measured in the frontal cortex of rats after either microinjection of bicuculline into the substantia inominata (the source of the cortical cholinergic innervation) or kainic acid lesioning of the nucleus accumbens (the source of GABAergic innervation of the substantia inominata). Neither treatment affected cortical acetylcholine metabolism, suggesting that the GABAergic inhibition of the substantia inominata-cortical cholinergic pathway is not tonic.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(85)90347-6