Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors
The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benz...
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| Veröffentlicht in: | Neuroscience letters 1985-02, Vol.53 (3), p.285-288 |
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| container_title | Neuroscience letters |
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| creator | Petersen, Erling N. Braestrup, Claus Scheel-Krüger, Jørgen |
| description | The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benzodiazepine antagonists Ro 15-1788, ZK 93426, FG 7142 and CGS 8216 produced strong antagonism of the effect of midazolam in doses not affecting the non-punished drinking behaviour. |
| doi_str_mv | 10.1016/0304-3940(85)90552-X |
| format | Article |
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Psychiatry ; Psychopharmacology ; Pyrazoles - pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, GABA-A - drug effects ; Ro 15-1788 ; ZK 93426</subject><ispartof>Neuroscience letters, 1985-02, Vol.53 (3), p.285-288</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8251f8f008d7fac78d755f216d78ec3b0a1e5d66bfe450dcf28ec0f950500b0e3</citedby><cites>FETCH-LOGICAL-c417t-8251f8f008d7fac78d755f216d78ec3b0a1e5d66bfe450dcf28ec0f950500b0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(85)90552-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8406740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2984608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petersen, Erling N.</creatorcontrib><creatorcontrib>Braestrup, Claus</creatorcontrib><creatorcontrib>Scheel-Krüger, Jørgen</creatorcontrib><title>Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benzodiazepine antagonists Ro 15-1788, ZK 93426, FG 7142 and CGS 8216 produced strong antagonism of the effect of midazolam in doses not affecting the non-punished drinking behaviour.</description><subject>amygdala</subject><subject>Amygdala - drug effects</subject><subject>Animals</subject><subject>anticonflict effect</subject><subject>benzodiazepine antagonists</subject><subject>Benzodiazepines - antagonists & inhibitors</subject><subject>Benzodiazepines - pharmacology</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbolines - pharmacology</subject><subject>CGS 8216</subject><subject>Conflict (Psychology)</subject><subject>FG 7142</subject><subject>Flumazenil</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Midazolam</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Pyrazoles - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Ro 15-1788</subject><subject>ZK 93426</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzv6DxSyENFF6U06qaQ2AzKMDxhwozC7kEpuNFIvk_RA9683Nd30Ujc5kPPdy-UcQl4yeM-AtR9gC6LZdgLeavmuAyl5c_eIbJhWvFGd4o_J5ow8Jc9y_g0AkklxQS54p0ULekPyzX30ODmk5Zct9UFqpxLdPIUhukIxBKwyBzpGbw_zYEcaJ2rH_U9vB0tjpiP6aAt62u8f5vOCLoboaI_TYa7eAZc4IU3ocClzys_Jk2CHjC9Oekl-fLr5fv2luf32-ev1x9vGCaZKo7lkQQcA7VWwTlWRMnDWeqXRbXuwDKVv2z6gkOBd4PUbQidBAvSA20vy5rh3SfOfHeZixpgdDoOdcN5lo1oQChT8F2SCcS65rqA4gi7NOScMZklxtGlvGJi1FLMmbtbEjZbmoRRzV8denfbv-prWeejUQvVfn3ybnR1CspOL-YxpAa0S65lXRwxraPcRk8kurt35WLMtxs_x33f8BQ4qqgA</recordid><startdate>19850204</startdate><enddate>19850204</enddate><creator>Petersen, Erling N.</creator><creator>Braestrup, Claus</creator><creator>Scheel-Krüger, Jørgen</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19850204</creationdate><title>Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors</title><author>Petersen, Erling N. ; Braestrup, Claus ; Scheel-Krüger, Jørgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8251f8f008d7fac78d755f216d78ec3b0a1e5d66bfe450dcf28ec0f950500b0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>amygdala</topic><topic>Amygdala - drug effects</topic><topic>Animals</topic><topic>anticonflict effect</topic><topic>benzodiazepine antagonists</topic><topic>Benzodiazepines - antagonists & inhibitors</topic><topic>Benzodiazepines - pharmacology</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbolines - pharmacology</topic><topic>CGS 8216</topic><topic>Conflict (Psychology)</topic><topic>FG 7142</topic><topic>Flumazenil</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Midazolam</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Pyrazoles - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Ro 15-1788</topic><topic>ZK 93426</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersen, Erling N.</creatorcontrib><creatorcontrib>Braestrup, Claus</creatorcontrib><creatorcontrib>Scheel-Krüger, Jørgen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petersen, Erling N.</au><au>Braestrup, Claus</au><au>Scheel-Krüger, Jørgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1985-02-04</date><risdate>1985</risdate><volume>53</volume><issue>3</issue><spage>285</spage><epage>288</epage><pages>285-288</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benzodiazepine antagonists Ro 15-1788, ZK 93426, FG 7142 and CGS 8216 produced strong antagonism of the effect of midazolam in doses not affecting the non-punished drinking behaviour.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2984608</pmid><doi>10.1016/0304-3940(85)90552-X</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1985-02, Vol.53 (3), p.285-288 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | amygdala Amygdala - drug effects Animals anticonflict effect benzodiazepine antagonists Benzodiazepines - antagonists & inhibitors Benzodiazepines - pharmacology Benzodiazepinones - pharmacology Biological and medical sciences Carbolines - pharmacology CGS 8216 Conflict (Psychology) FG 7142 Flumazenil Male Medical sciences Midazolam Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrazoles - pharmacology Rats Rats, Inbred Strains Receptors, GABA-A - drug effects Ro 15-1788 ZK 93426 |
| title | Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors |
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