Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors

The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benz...

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Veröffentlicht in:	Neuroscience letters 1985-02, Vol.53 (3), p.285-288
Hauptverfasser:	Petersen, Erling N., Braestrup, Claus, Scheel-Krüger, Jørgen
Format:	Artikel
Sprache:	eng
Schlagworte:	amygdala Amygdala - drug effects Animals anticonflict effect benzodiazepine antagonists Benzodiazepines - antagonists & inhibitors Benzodiazepines - pharmacology Benzodiazepinones - pharmacology Biological and medical sciences Carbolines - pharmacology CGS 8216 Conflict (Psychology) FG 7142 Flumazenil Male Medical sciences Midazolam Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrazoles - pharmacology Rats Rats, Inbred Strains Receptors, GABA-A - drug effects Ro 15-1788 ZK 93426
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Zusammenfassung:	The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benzodiazepine antagonists Ro 15-1788, ZK 93426, FG 7142 and CGS 8216 produced strong antagonism of the effect of midazolam in doses not affecting the non-punished drinking behaviour.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(85)90552-X