Poly(A) tail metabolism and function in eucaryotes
Recent work on the homopolymeric poly(A) tail of eucaryotic mRNA has led to a clearer understanding of its synthesis, degradation, and function. This review will emphasize the key insights of these studies and attempt to summarize current working models. Two recurring themes in poly(A) research, the...
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| Veröffentlicht in: | The Journal of biological chemistry 1993-11, Vol.268 (31), p.22955-22958 |
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| container_issue | 31 |
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| container_title | The Journal of biological chemistry |
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| creator | SACHS, A WAHLE, E |
| description | Recent work on the homopolymeric poly(A) tail of eucaryotic mRNA has led to a clearer understanding of its synthesis, degradation, and function. This review will emphasize the key insights of these studies and attempt to summarize current working models. Two recurring themes in poly(A) research, the recruitment of enzymes by RNA binding proteins and the recognition of degenerate RNA sequences by combinations of RNA binding proteins, will be highlighted. |
| doi_str_mv | 10.1016/s0021-9258(19)49408-8 |
| format | Article |
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| ispartof | The Journal of biological chemistry, 1993-11, Vol.268 (31), p.22955-22958 |
| issn | 0021-9258 1083-351X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Cell Nucleus - metabolism Eukaryotic Cells - metabolism Fundamental and applied biological sciences. Psychology Molecular and cellular biology Molecular genetics Oocytes - metabolism Poly A - metabolism Poly(A)-Binding Proteins RNA-Binding Proteins - metabolism Transcription. Transcription factor. Splicing. Rna processing |
| title | Poly(A) tail metabolism and function in eucaryotes |
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