Poly(A) tail metabolism and function in eucaryotes

Recent work on the homopolymeric poly(A) tail of eucaryotic mRNA has led to a clearer understanding of its synthesis, degradation, and function. This review will emphasize the key insights of these studies and attempt to summarize current working models. Two recurring themes in poly(A) research, the...

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Veröffentlicht in:	The Journal of biological chemistry 1993-11, Vol.268 (31), p.22955-22958
Hauptverfasser:	SACHS, A, WAHLE, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Nucleus - metabolism Eukaryotic Cells - metabolism Fundamental and applied biological sciences. Psychology Molecular and cellular biology Molecular genetics Oocytes - metabolism Poly A - metabolism Poly(A)-Binding Proteins RNA-Binding Proteins - metabolism Transcription. Transcription factor. Splicing. Rna processing
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Beschreibung
Zusammenfassung:	Recent work on the homopolymeric poly(A) tail of eucaryotic mRNA has led to a clearer understanding of its synthesis, degradation, and function. This review will emphasize the key insights of these studies and attempt to summarize current working models. Two recurring themes in poly(A) research, the recruitment of enzymes by RNA binding proteins and the recognition of degenerate RNA sequences by combinations of RNA binding proteins, will be highlighted.
ISSN:	0021-9258 1083-351X
DOI:	10.1016/s0021-9258(19)49408-8