Syntheses and Hypotensive Properties of Substituted 2-Aminotetralins

The synthesis and activity in the spontaneously hypertensive rat of several 4-(1,2,3,4-tetrahydronaphthyl-2-amino)-1-(4-fluorophenyl)-1-butanones is reported. Maximal antihypertensive activity was associated with 5,6-dimethoxy substitution in the aminotetralin moiety.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1985-01, Vol.74 (1), p.37-39
Hauptverfasser:	Repke, David B., Clark, Robin D., Kluge, Arthur F., Muchowski, Joseph M., Strosberg, Arthur M., Lee, Chi-Ho, Whiting, Roger L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Animals Antihypertensive Agents - chemical synthesis Applied sciences Blood Pressure - drug effects Chemical Phenomena Chemistry Exact sciences and technology In Vitro Techniques Male Naphthalenes - chemical synthesis Organic chemistry Other techniques and industries Preparations and properties Rats Rats, Inbred SHR Tetrahydronaphthalenes - chemical synthesis
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Beschreibung
Zusammenfassung:	The synthesis and activity in the spontaneously hypertensive rat of several 4-(1,2,3,4-tetrahydronaphthyl-2-amino)-1-(4-fluorophenyl)-1-butanones is reported. Maximal antihypertensive activity was associated with 5,6-dimethoxy substitution in the aminotetralin moiety.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600740110