Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis
Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet...
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| Veröffentlicht in: | Neuroscience letters 1993-07, Vol.157 (1), p.91-94 |
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| container_title | Neuroscience letters |
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| creator | Weiss, Gerald K. Castillo, Natalie Fernandez, Michael |
| description | Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucorcorticoids, play a role in epileptogenesis. |
| doi_str_mv | 10.1016/0304-3940(93)90650-A |
| format | Article |
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Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucorcorticoids, play a role in epileptogenesis.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(93)90650-A</identifier><identifier>PMID: 8233039</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amygdala - physiology ; Animals ; Biological and medical sciences ; Circadian rhythm ; Circadian Rhythm - physiology ; Corticosterone ; Corticotropin-Releasing Hormone - physiology ; Cortisone - administration & dosage ; Cortisone - pharmacology ; Drug Implants ; Electrodes, Implanted ; Fischer rat ; HPA axis ; Hypothalamo-Hypophyseal System - physiology ; Kindling ; Kindling, Neurologic - physiology ; Lewis rat ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Pituitary-Adrenal System - physiology ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew</subject><ispartof>Neuroscience letters, 1993-07, Vol.157 (1), p.91-94</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-43d243ed7058272203abc6165263bdf07f9e9ef281bb8467a268a8d8cee345f63</citedby><cites>FETCH-LOGICAL-c417t-43d243ed7058272203abc6165263bdf07f9e9ef281bb8467a268a8d8cee345f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(93)90650-A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4834431$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8233039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiss, Gerald K.</creatorcontrib><creatorcontrib>Castillo, Natalie</creatorcontrib><creatorcontrib>Fernandez, Michael</creatorcontrib><title>Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucorcorticoids, play a role in epileptogenesis.</description><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Corticosterone</subject><subject>Corticotropin-Releasing Hormone - physiology</subject><subject>Cortisone - administration & dosage</subject><subject>Cortisone - pharmacology</subject><subject>Drug Implants</subject><subject>Electrodes, Implanted</subject><subject>Fischer rat</subject><subject>HPA axis</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Kindling</subject><subject>Kindling, Neurologic - physiology</subject><subject>Lewis rat</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzv6DxSyENFFaV6VpDYDzeALBtzoOqSSm-loVapM0uP0v7dquumlrgLnfvdwcw5CLyl5TwmVHwgnouGdIG87_q4jsiXN9hHaUK1YozrFHqPNGXmKnpXykxDS0lZcoAvNOCe826D77Xi49Xaw-FdMfojpFmdbAceC7VAhg8cxrVLBf2LdYYs9hOhiXeW6A5yhzFMq8Q4SlIKn8KDuDvNUd4vtODVzrPtYbT401mdIdsD2Ppbn6EmwQ4EXp_cS_fj08fv1l-bm2-ev19ubxgmqaiO4Z4KDV6TVTDFGuO2dpLJlkvc-EBU66CAwTfteC6ksk9pqrx0AF22Q_BK9OfrOefq9h1LNGIuDYbAJpn0xShLRKq7-C1Kp2HJFu4DiCLo8lZIhmDnHcfmfocSszZg1drPGbjpuHpox22Xt1cl_34_gz0unKpb569PcFmeHkG1ysZwxobkQnC7Y1RGDJbS7CNkUFyE58DGDq8ZP8d93_AW3Varb</recordid><startdate>19930709</startdate><enddate>19930709</enddate><creator>Weiss, Gerald K.</creator><creator>Castillo, Natalie</creator><creator>Fernandez, Michael</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930709</creationdate><title>Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis</title><author>Weiss, Gerald K. ; Castillo, Natalie ; Fernandez, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-43d243ed7058272203abc6165263bdf07f9e9ef281bb8467a268a8d8cee345f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Corticosterone</topic><topic>Corticotropin-Releasing Hormone - physiology</topic><topic>Cortisone - administration & dosage</topic><topic>Cortisone - pharmacology</topic><topic>Drug Implants</topic><topic>Electrodes, Implanted</topic><topic>Fischer rat</topic><topic>HPA axis</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Kindling</topic><topic>Kindling, Neurologic - physiology</topic><topic>Lewis rat</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Lew</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiss, Gerald K.</creatorcontrib><creatorcontrib>Castillo, Natalie</creatorcontrib><creatorcontrib>Fernandez, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, Gerald K.</au><au>Castillo, Natalie</au><au>Fernandez, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1993-07-09</date><risdate>1993</risdate><volume>157</volume><issue>1</issue><spage>91</spage><epage>94</epage><pages>91-94</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucorcorticoids, play a role in epileptogenesis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8233039</pmid><doi>10.1016/0304-3940(93)90650-A</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1993-07, Vol.157 (1), p.91-94 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76045737 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amygdala - physiology Animals Biological and medical sciences Circadian rhythm Circadian Rhythm - physiology Corticosterone Corticotropin-Releasing Hormone - physiology Cortisone - administration & dosage Cortisone - pharmacology Drug Implants Electrodes, Implanted Fischer rat HPA axis Hypothalamo-Hypophyseal System - physiology Kindling Kindling, Neurologic - physiology Lewis rat Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Pituitary-Adrenal System - physiology Rats Rats, Inbred F344 Rats, Inbred Lew |
| title | Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis |
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