Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis

Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet...

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Veröffentlicht in:	Neuroscience letters 1993-07, Vol.157 (1), p.91-94
Hauptverfasser:	Weiss, Gerald K., Castillo, Natalie, Fernandez, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - physiology Animals Biological and medical sciences Circadian rhythm Circadian Rhythm - physiology Corticosterone Corticotropin-Releasing Hormone - physiology Cortisone - administration & dosage Cortisone - pharmacology Drug Implants Electrodes, Implanted Fischer rat HPA axis Hypothalamo-Hypophyseal System - physiology Kindling Kindling, Neurologic - physiology Lewis rat Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Pituitary-Adrenal System - physiology Rats Rats, Inbred F344 Rats, Inbred Lew
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Zusammenfassung:	Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucorcorticoids, play a role in epileptogenesis.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(93)90650-A