Carboxyethyl γ-aminobutyric acid, a polyamine derivative molecule with a growth effect on hybridomas

An increased proliferation of hybridomas is induced by a polyamine derivative molecule, CEGABA (carboxyethyl gamma-aminobutyric acid). The effects of CEGABA and CR-ECGS (endothelial cell growth supplement) on hybridoma growth are similar. However, both factors are less efficient than HECS (human end...

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Veröffentlicht in:	Journal of immunological methods 1985-03, Vol.77 (2), p.229-235
Hauptverfasser:	Cerino, Antonella, De Amici, Mara, Fussi, Fernando F., C.B. Astaldi Ricotti, Giulia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CEGABA Cell Division - drug effects Cell Fusion Fundamental and applied biological sciences. Psychology Fundamental immunology gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology growth factors Growth Substances - pharmacology Hybrid Cells - cytology hybridoma cultures Hybridomas - cytology Immunobiology Immunological reactions in vitro Lymphoid cell lines. Hybrids media supplements Mice Polyamines - pharmacology
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Zusammenfassung:	An increased proliferation of hybridomas is induced by a polyamine derivative molecule, CEGABA (carboxyethyl gamma-aminobutyric acid). The effects of CEGABA and CR-ECGS (endothelial cell growth supplement) on hybridoma growth are similar. However, both factors are less efficient than HECS (human endothelial culture supernatant) in inducing hybridoma growth through all the steps of hybridoma production, including: recovery after fusion, cloning, and proliferation.
ISSN:	0022-1759 1872-7905
DOI:	10.1016/0022-1759(85)90035-3