Effects of phenobarbital and p, p′-DDT on carboxylesterase activity and hydrolysis of propanidid in rat liver

1. Time-dependent responses of microsomal and cytosolic carboxylesterases (EC 3.1.1.1) to administration of phenobarbital or p, p′-DDT were studied in rat liver using p-nitrophenylacetate and propanidid as substrates. 2. In vitro and in vivo studies indicate that the hepatic carboxylesterases are in...

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Veröffentlicht in:	General pharmacology 1985, Vol.16 (1), p.49-53
1. Verfasser:	Nousiainen, Unto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxylic Ester Hydrolases - metabolism Cytochrome P-450 Enzyme System - metabolism Cytosol - enzymology DDT - pharmacology Half-Life Hydrolysis Kinetics Liver - enzymology Liver - metabolism Male Microsomes, Liver - enzymology Phenobarbital - pharmacology Propanidid - metabolism Rats Rats, Inbred Strains Time Factors
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Zusammenfassung:	1. Time-dependent responses of microsomal and cytosolic carboxylesterases (EC 3.1.1.1) to administration of phenobarbital or p, p′-DDT were studied in rat liver using p-nitrophenylacetate and propanidid as substrates. 2. In vitro and in vivo studies indicate that the hepatic carboxylesterases are induced by phenobarbital and p, p′-DDT. 3. The induced metabolism of propanidid does not appear to be due to the microsomal polysubstrate monooxygenase system of the liver.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(85)90269-1