Primary Dose-Dependent Pharmacokinetic Study of Veralipride
A dose-dependent pharmacokinetic study of veralipride (a new post-menopausal “hot flushes” regulator) was developed in humans after oral solution administration (100, 150, 200, and 250 mg). In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1985-01, Vol.74 (1), p.94-96 |
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| container_end_page | 96 |
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| container_issue | 1 |
| container_start_page | 94 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 74 |
| creator | Staveris, S. Houin, G. Tillement, J.P. Jamet, G. Schneider, M. Jung, L. Koffel, J.C. |
| description | A dose-dependent pharmacokinetic study of veralipride (a new post-menopausal “hot flushes” regulator) was developed in humans after oral solution administration (100, 150, 200, and 250 mg). In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of absorption. From model independent pharmacokinetic parameters, it can be concluded that a linearity in the tested range doses exists. |
| doi_str_mv | 10.1002/jps.2600740126 |
| format | Article |
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In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of absorption. From model independent pharmacokinetic parameters, it can be concluded that a linearity in the tested range doses exists.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600740126</identifier><identifier>PMID: 3981429</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Hormones. Endocrine system ; Humans ; Kinetics ; Medical sciences ; Pharmacology. 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Pharm. Sci</addtitle><description>A dose-dependent pharmacokinetic study of veralipride (a new post-menopausal “hot flushes” regulator) was developed in humans after oral solution administration (100, 150, 200, and 250 mg). In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of absorption. From model independent pharmacokinetic parameters, it can be concluded that a linearity in the tested range doses exists.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Sulpiride - analogs & derivatives</subject><subject>Sulpiride - blood</subject><subject>Sulpiride - metabolism</subject><subject>Sulpiride - urine</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1EVZbClRtSDohbtmMndmxxoltailpYKB9Ha9YZC7fZJNjZwv77BmW1iAPi5MP7vDOeh7FnHOYcQBzf9GkuFEBVAhfqAZtxKSBXwKuHbDYCIi9kaR6xxyndAIACKQ_ZYWE0L4WZsVfLGNYYt9lplyg_pZ7amtohW37HuEbX3YaWhuCy62FTb7POZ18pYhP6GGp6wg48Nome7t4j9uXszefF2_zyw_nF4vVl7krNVa4QOeee0CNw71ZaliDBUO3FqiwMSTIFIqEulSblidMKuRkjyYX3lSmO2Mtpbh-7HxtKg12H5KhpsKVuk2yloNClFCM4n0AXu5QiedtP11kO9rctO9qyf2yNhee7yZvVmuo9vtMz5i92OSaHjY_YupD2mJZFZUCPmJmwn6Gh7X-W2nfL67--kE_dkAb6te9ivLWqKippv70_t1cn4uOnamHs1cjriafR-F2gaJML1DqqQyQ32LoL_7r2HqOUpJE</recordid><startdate>198501</startdate><enddate>198501</enddate><creator>Staveris, S.</creator><creator>Houin, G.</creator><creator>Tillement, J.P.</creator><creator>Jamet, G.</creator><creator>Schneider, M.</creator><creator>Jung, L.</creator><creator>Koffel, J.C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198501</creationdate><title>Primary Dose-Dependent Pharmacokinetic Study of Veralipride</title><author>Staveris, S. ; Houin, G. ; Tillement, J.P. ; Jamet, G. ; Schneider, M. ; Jung, L. ; Koffel, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4816-6aa111feafa01fcb8540509edf2b439e5e93aaea8468e6fe1eba19b43512ff793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Pharmacology. 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Pharm. Sci</addtitle><date>1985-01</date><risdate>1985</risdate><volume>74</volume><issue>1</issue><spage>94</spage><epage>96</epage><pages>94-96</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>A dose-dependent pharmacokinetic study of veralipride (a new post-menopausal “hot flushes” regulator) was developed in humans after oral solution administration (100, 150, 200, and 250 mg). In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of absorption. From model independent pharmacokinetic parameters, it can be concluded that a linearity in the tested range doses exists.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>3981429</pmid><doi>10.1002/jps.2600740126</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1985-01, Vol.74 (1), p.94-96 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76038452 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Dose-Response Relationship, Drug Hormones. Endocrine system Humans Kinetics Medical sciences Pharmacology. Drug treatments Sulpiride - analogs & derivatives Sulpiride - blood Sulpiride - metabolism Sulpiride - urine |
| title | Primary Dose-Dependent Pharmacokinetic Study of Veralipride |
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