Primary Dose-Dependent Pharmacokinetic Study of Veralipride

Primary Dose-Dependent Pharmacokinetic Study of Veralipride

A dose-dependent pharmacokinetic study of veralipride (a new post-menopausal “hot flushes” regulator) was developed in humans after oral solution administration (100, 150, 200, and 250 mg). In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of...

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Veröffentlicht in:Journal of pharmaceutical sciences 1985-01, Vol.74 (1), p.94-96
Hauptverfasser: Staveris, S., Houin, G., Tillement, J.P., Jamet, G., Schneider, M., Jung, L., Koffel, J.C.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Dose-Response Relationship, Drug
Hormones. Endocrine system
Humans
Kinetics
Medical sciences
Pharmacology. Drug treatments
Sulpiride - analogs & derivatives
Sulpiride - blood
Sulpiride - metabolism
Sulpiride - urine
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Beschreibung
Zusammenfassung:A dose-dependent pharmacokinetic study of veralipride (a new post-menopausal “hot flushes” regulator) was developed in humans after oral solution administration (100, 150, 200, and 250 mg). In most cases, two maxima of plasma drug concentrations occurred, probably due to a double intestinal site of absorption. From model independent pharmacokinetic parameters, it can be concluded that a linearity in the tested range doses exists.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600740126